Causes Of Impaired Drug Delivery To Cancer Cells

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Barriers to drug delivery in solid tumors

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106925/
    Jul 22, 2014 · Introduction. Cancer accounts for the deaths of millions of people worldwide. It occurs when normal cells acquire a series of critical mutations leading to their uncontrolled cell growth. 1 The fact that cancer originates from an organisms own cells makes it harder to selectively treat. Current clinical approaches are based on the systemic administration of chemotherapeutics drugs.Author: Shravan Kumar Sriraman, Bhawani Aryasomayajula, Vladimir P Torchilin

Combining two strategies to improve perfusion and drug ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832007/
    Nov 12, 2013 · Intratumoral distribution is defined as the fraction of the tumor in which the drug is bound to cancer cells in amounts higher than 1% of the concentration at the inlet of the vascular network. Delivery is improved with improved perfusion for drugs of all sizes, and the effect is more prominent for small drugs with low binding affinity.Author: Triantafyllos Stylianopoulos, Rakesh K. Jain

Delta like ligand 4 induces impaired chemo-drug delivery ...

    https://www.sciencedirect.com/science/article/pii/S0304383512006623
    Delta like ligand 4 induces impaired chemo-drug delivery and enhanced chemoresistance in pancreatic cancer. Author links open overlay panel Muxing Kang a b Biao Jiang c Bin Xu a Wenjie Lu a Qingqu Guo a b Qiuping Xie a b Bo Zhang a b Xin Dong a Daniel Chen d Yulian Wu a b. ... and impaired …Author: Muxing Kang, Biao Jiang, Bin Xu, Wenjie Lu, Qingqu Guo, Qiuping Xie, Bo Zhang, Xin Dong, Daniel Chen...

Nano packages for anti-cancer drug delivery

    https://phys.org/news/2015-03-nano-packages-anti-cancer-drug-delivery.html
    Mar 18, 2015 · Cancer stem cells are resistant to chemotherapy and consequently tend to remain in the body even after a course of treatment has finished, where they can …

ABSTRACT:Minnelide Causes Stromal Lysis and Improves Drug ...

    https://www.researchgate.net/publication/275644694_ABSTRACTMinnelide_Causes_Stromal_Lysis_and_Improves_Drug_Delivery_in_Pancreatic_Cancer
    ABSTRACT:Minnelide Causes Stromal Lysis and Improves Drug Delivery in Pancreatic Cancer Article in Pancreas 43(8):1340-1429 · November 2014 with 49 Reads How we measure 'reads'

Targeting cancer cells with nanotherapeutics and ...

    https://www.sciencedirect.com/science/article/pii/S1044579X20300134
    The “nano-cocoon” DNA-based drug delivery system may offer several advantages over other nanotechnology-derived delivery systems. This technique can specifically target cancer cells, and can carry a large drug load and release the drug very quickly once inside the cancer cell.Author: Eunus S. Ali, Shazid Md. Sharker, Muhammad Torequl Islam, Ishaq N. Khan, Subrata Shaw, Md. Atiqur Ra...

Drug combination therapy causes cancer cells to 'eat ...

    https://medicalxpress.com/news/2013-11-drug-combination-therapy-cancer-cells.html
    Nov 05, 2013 · Researchers design new technology for targeted cancer drug delivery. 23 hours ago. ... Drug combination therapy causes cancer cells to 'eat themselves' Your friend's email. Your email.

New drug delivery method for cancer therapy developed ...

    https://www.sciencedaily.com/releases/2017/03/170316151821.htm
    Mar 16, 2017 · Dec. 2, 2015 — A new drug delivery technique has been developed that uses a biodegradable liquid metal to target cancer cells. The liquid metal drug delivery method promises to boost the effect ...

Targeted and controlled anticancer drug delivery and ...

    https://www.nature.com/articles/srep20867
    Feb 15, 2016 · An important challenge in treating cancer in general is to find a technology for a controlled targeted drug delivery and release to eradicate tumor cells while sparing normal cells.Author: Alexandra Rodzinski, Rakesh Guduru, Ping Liang, Ali Hadjikhani, Tiffanie Stewart, Emmanuel Stimphil,...

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