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https://www.sciencedirect.com/science/article/pii/S0168365918301202
The clinical success of chimeric antigen receptor (CAR) T cell immunotherapy in treating multiple blood cancers has created a need for efficient methods of ex vivo gene delivery to primary human T cells for cell engineering. Here, we synthesize and evaluate a panel of cationic polymers for gene delivery to both cultured and primary human T cells.Author: Brynn R. Olden, Yilong Cheng, Jonathan L. Yu, Suzie H. Pun
https://link.springer.com/article/10.1023%2FA%3A1007548826495
Feb 01, 2000 · Gene transfer to humans requires carriers for the plasmid DNA which canefficiently and safely carrythe gene into the nucleus of the desired cells. A series of chemically differentcationic polymers arecurrently being investigated for these purposes. Although many cationic polymersindeed condense DNAspontaneously, which is a requirement for gene transfer in most types of cells,the ...Author: Stefaan C. De Smedt, Joseph Demeester, Wim E. Hennink
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294582/
Chitosan, a naturally occurring cationic polysaccharide is an attractive candidate for gene delivery because of its several advantages, such as biocompatibility, biodegradability and low toxicity [63, 64]. Mumper et al. introduced chitosan as a non-viral vector for gene delivery. The primary amine groups of chitosan can readily form complexes ...Author: Sutapa Barua, James Ramos, Thrimoorthy Potta, David Taylor, Huang Chiao Huang, Gabriela Montanez, Ka...
https://www.sciencedirect.com/science/article/pii/S0168365906002045
We evaluate the structural features of cationic compounds and discuss which groups may increase the toxicity, what kind of linkages have relatively short half-life, and how proper modifications will decrease the toxicity of cationic lipids and cationic polymers for gene delivery. 2. Cationic lipidsAuthor: Hongtao Lv, Hongtao Lv, Shubiao Zhang, Bing Wang, Shaohui Cui, Jie Yan
https://www.nature.com/articles/nrd1775
Jul 01, 2005 · The use of cationic lipids for gene delivery was first reported by Felgner in 1987 24.The lipid structures affect the interactions of the lipids with DNA and influence the membrane properties of ...Author: Daniel W. Pack, Allan S. Hoffman, Suzie Pun, Patrick S. Stayton
https://pubs.acs.org/doi/10.1021/bc990025r
Cationic polymer/DNA complexes are widely used for gene delivery, although the influence of the cationic polymer on the biophysical properties of the resulting complex is poorly understood. Here, several series of cationic polymers have been used to evaluate the influence of structural parameters on properties of DNA complexes. Parameters studied included the length of side chain, charge type ...Author: Margreet A. Wolfert, Philip R. Dash, Ola Nazarova, David Oupicky, Leonard W. Seymour, Sarah Smart, J...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567174/
Sep 02, 2015 · Influence of cationic lipid concentration on properties of lipid–polymer hybrid nanospheres for gene delivery. ... Nanoparticles have been widely used for nonviral gene delivery. Recently, cationic hybrid nanoparticles consisting of two different materials were suggested as a promising delivery vehicle.Author: Rajendran Jc Bose, Yoshie Arai, Jong Chan Ahn, Hansoo Park, Soo-Hong Lee
https://pubs.acs.org/doi/10.1021/bc0000177
Advancing biotechnology spurs the development of new pharmaceutically engineered gene delivery vehicles. Poly(l-histidine) {PLH} has been shown to induce membrane fusion at endosomal pH values, whereas PLL has a well documented efficacy in polyplex formation. Therefore, N-Ac-poly(l-histidine)-graft-poly(l-lysine) {PLH-g-PLL} was synthesized by grafting poly(l-histidine) to poly(l-lysine) {PLL}.Author: Jonathan M. Benns, ‡ Joon-Sig Choi, Ram I. Mahato, ‡ and Jong-Sang Park, Sung Wan Kim
https://www.mdpi.com/journal/polymers/special_issues/polymers_in_gene_delivery
In 1987, Felgner et al. used the cationic lipid based non-viral gene delivery system for the very first time. This breakthrough opened the opportunity for other non-viral vectors, such as polymers. Cationic polymers have emerged as promising candidates for non-viral gene delivery systems because of their facile synthesis and flexible properties.
https://www.researchgate.net/publication/237882931_Hydrophobic_modifications_of_cationic_polymers_for_gene_delivery
Cationic polymers are the subject of intense research as non-viral gene delivery systems, due to their flexible properties, facile synthesis, robustness, and proven gene delivery efficiency.
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