We have collected information about Cationic Polymer Based Gene Delivery Systems for you. Follow the links to find out details on Cationic Polymer Based Gene Delivery Systems.
https://link.springer.com/article/10.1023%2FA%3A1007548826495
Feb 01, 2000 · Gene transfer to humans requires carriers for the plasmid DNA which canefficiently and safely carrythe gene into the nucleus of the desired cells. A series of chemically differentcationic polymers arecurrently being investigated for these purposes. Although many cationic polymersindeed condense DNAspontaneously, which is a requirement for gene transfer in most types of cells,the ...Author: Stefaan C. De Smedt, Joseph Demeester, Wim E. Hennink
https://www.researchgate.net/publication/226524947_Cationic_Polymer_Based_Gene_Delivery_Systems
Therefore, conventional cationic gene or drug delivery systems are prone to aggregate with negatively-charged serum protein due to the electrostatic interaction and to be eliminated via renal ...
https://www.sciencedirect.com/science/article/pii/S0168365918301202
Cationic lipid and polymer-based reagents have been developed extensively as gene delivery vehicles . Unlike viruses, these materials are not limited to a size or type of genetic cargo they can carry.Author: Brynn R. Olden, Yilong Cheng, Jonathan L. Yu, Suzie H. Pun
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417261/
Mar 12, 2019 · The non-viral gene delivery systems have also treated for the physicochemical approaches such as physical method and chemical method. Several kinds of gene delivery systems have discussed on the gene delivery systems of cationic biomedical polymers such as polysaccharides, polyethylenimine (PEI), and poly(L-lysine)(PLL) derivatives.Author: YK Sung, SW Kim
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · INTRODUCTION. Basically gene therapy is an intracellular delivery of genomic materials (transgene) into specific cells to generate a therapeutic effect by correcting an existing abnormality or providing the cells with a new function.[] Different types of gene delivery systems may be applied in gene therapy to restore a specific gene function or turning off a special gene(s).
https://www.researchgate.net/publication/289718261_Polymer-Based_Gene_Delivery_Systems
Polymer-Based Gene Delivery Systems. ... the myotoxic potential of selected non-viral gene delivery macromolecules (e.g., cationic lipids and polymers) with and without plasmid DNA (pDNA) in vitro ...
https://www.sciencedirect.com/science/article/pii/S0169409X19300547
6. Polymer-based siRNA delivery. The utility of polymers to function as intracellular delivery systems for nucleic acids, including antisense oligonucleotides (ASOs) and plasmid DNA (pDNA), has been studied for several decades [97,98]. For instance, cationic polymers are able to condense nucleic acids into polyplexes via electrostatic ...Author: Yizhou Dong, Daniel J. Siegwart, Daniel G. Anderson
https://www.mdpi.com/journal/polymers/special_issues/polymers_in_gene_delivery
In 1987, Felgner et al. used the cationic lipid based non-viral gene delivery system for the very first time. This breakthrough opened the opportunity for other non-viral vectors, such as polymers. Cationic polymers have emerged as promising candidates for non-viral gene delivery systems because of their facile synthesis and flexible properties.
https://biblio.ugent.be/publication/170895
De Smedt, Stefaan, Jo Demeester, and WE HENNINK. 2000. “Cationic Polymer Based Gene Delivery Systems.” Pharmaceutical Research 17 (2): 113–126.Author: Stefaan C. De Smedt, Joseph Demeester, Wim E. Hennink
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(02)00031-X
Jan 01, 2003 · Cationic lipid and polymer-based gene delivery to human pancreatic islets. ... The authors also demonstrated poor transfection by these gene delivery systems into intact mouse, rat and canine islets. However, it is important to note that dispersion of islets by trypsin treatment could lead to efficient transfection by LipofectAMINE- and ...Author: Ram I Mahato, James Henry, Ajit S Narang, Omaima Sabek, Daniel Fraga, Malak Kotb, A.Osama Gaber
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