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https://www.sciencedirect.com/science/article/pii/S0168365901002486
As shown in Fig. 1, burst release leads to higher initial drug delivery and also reduces the effective lifetime of the device. Because burst release happens in a very short time compared to the entire release process, it has not been specifically investigated in most published results, and it has been ignored in most mathematical models.Author: Xiao Huang, Christopher S Brazel
https://pubs.acs.org/doi/full/10.1021/jacs.9b10765
Programming Drug Delivery Kinetics for Active Burst Release with DNA Toehold Switches Mingshu Xiao Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai 200241, ChinaAuthor: Mingshu Xiao, Wei Lai, Fei Wang, Li Li, Chunhai Fan, Hao Pei
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/drug-release
In most cases, rapid drug release from polymer nanoparticles, called “ burst release”, can be observed initially. It is reported that the release profiles of the drugs from polymer nanoparticles depend upon the nature of the delivery system.
https://www.researchgate.net/post/what_are_the_causes_of_burst_drug_release
burst release mechanisms depend on the nature of the drug delivery system. In short: If your system is nanoparticles burst release is due to the high specific surface that is in contact with external media or the instability of nanoparticles in the media.
https://www.researchgate.net/publication/11828180_On_the_importance_and_mechanisms_of_burst_release_in_matrix-controlled_drug_delivery_systems
Instant, or burst, drug release by MNs is an important concept but was often ignored in MN-based controlled drug delivery because it was often considered a negative result when creating long-term...
https://pubs.acs.org/doi/10.1021/bm8013632
This work has demonstrated that it is possible to exercise a wide range of control over both the initial burst release and the final drug release times from porous polylactide (PLA) devices derived from cocontinuous polymer blends. Two strategies were used: a layer-by-layer polyelectrolyte surface deposition approach on the porous PLA surface and the application of a partially closed-cell ...Author: Zhenyu Xiang, Pierre Sarazin, Basil D. Favis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846103/
In case studies of release kinetics, burst release is a phenomenon commonly observed in delivery devices of different forms and compositions. The burst effect may be favorable for certain indications or applications such as wound treatment, encapsulated flavors, targeted delivery and pulsatile release.Author: Yao Fu, Weiyuan John Kao
https://www.tandfonline.com/doi/abs/10.1517/17425247.5.6.615
Sep 26, 2008 · While the initial burst release of drug is not always detrimental, excessive drug release in the burst phase may be toxic, and irregularity in the amount of drug released (e.g., from batch to batch) is not acceptable.Author: S Dean Allison
https://www.nature.com/articles/s41598-017-05898-6
Jul 17, 2017 · The rapid release at the initial stage will result in a high plasma drug level, which will pose a serious toxicity threat for the patients 8. For example, biodegradable microspheres, which were extensively investigated for peptide release, usually suffer from a significant initial burst release 8, 12.Author: Ya-Nan Zhao, Xiaoyu Xu, Na Wen, Rui Song, Qingbin Meng, Ying Guan, Siqi Cheng, Danni Cao, Yansheng D...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142099/
Sep 28, 2014 · The controlled drug delivery technology has progressed over the last six decades. It began in 1952 with the introduction of the first sustained release formulation. The 1st generation (1950-1980) of drug delivery was focused on developing oral and transdermal sustained release systems and establishing the controlled drug release mechanisms.Author: Kinam Park
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