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https://www.sciencedirect.com/science/article/pii/S0168365901002486
The chemical and physical structure of various drug or active agent molecules can also have a profound effect on the burst effect in controlled release systems. The burst effect has been noted to occur in systems with both small molecular weight solutes and those for delivery of peptides and proteins.Author: Xiao Huang, Christopher S Brazel
https://pubs.acs.org/doi/abs/10.1021/bk-2004-0879.ch019
May 05, 2004 · In most pharmaceutical applications, the burst effect is regarded as an event to be avoided, even at the cost of using an overcoat to reduce the initial burst. At minimum, burst release leads to a loss in treatment efficacy, as drug is lost in an uncontrolled and unpredictable pattern.
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/drug-release
Drug release when loaded by covalent attachment on the particle system is affected almost solely by drug–NM diffusion. This system has a relatively small burst effect and sustained release characteristics. 119 When the drug is encapsulated inside a NM, the release is controlled by diffusion of the drug …
https://engineering.lehigh.edu/research/resolve/volume-1-2008/anthony-mchugh-exploding-burst-effect
The fabrication of drug-delivery systems, a multibillion-dollar industry, is faced with two competing challenges: achieving sufficient drug load (DL) in delivery media while avoiding the socalled “burst effect.”This burst effect – in which a large drug volume is quickly released into the body – …
https://pubs.acs.org/doi/pdfplus/10.1021/bk-2004-0879.ch019
The burst effect is a major detrimental side effect of many controlled release systems, carrying the risk of exposing the patient to a local or temporal drug overdose. Besides being adverse to the patient, the burst effect is economically inefficient, as much of the often costly pharmaceutical agent is lost from a
https://www.researchgate.net/post/what_are_the_causes_of_burst_drug_release
burst release mechanisms depend on the nature of the drug delivery system. In short: If your system is nanoparticles burst release is due to the high specific surface that is in contact with external media or the instability of nanoparticles in the media.
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