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https://www.sciencedirect.com/science/article/pii/S0168365901002486
Although favorable in some limited situations, under most of the circumstances in drug delivery, burst release is considered a negative effect. The importance of avoiding burst release can be seen in the number of publications focused on developing methods to prevent or minimize the burst effect in a wide range of polymer/drug systems.Author: Xiao Huang, Christopher S Brazel
https://www.researchgate.net/post/what_are_the_causes_of_burst_drug_release
What are the causes of burst drug release ?? i want to know the factors control the burst effect in a modified drug release systems ? ... did not give the properties of your drug delivery systems ...
https://pubs.acs.org/doi/abs/10.1021/bk-2004-0879.ch019
May 05, 2004 · The burst effect is a major consideration in designing controlled release systems. In most pharmaceutical applications, the burst effect is regarded as an event to be avoided, even at the cost of using an overcoat to reduce the initial burst. At minimum, burst release leads to a loss in treatment efficacy, as drug is lost in an uncontrolled and unpredictable pattern. We used an experimental ...
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/drug-release
Drug release when loaded by covalent attachment on the particle system is affected almost solely by drug–NM diffusion. This system has a relatively small burst effect and sustained release characteristics. 119 When the drug is encapsulated inside a NM, the release is controlled by …
https://glosbe.com/en/en/burst%20effect
There is provided a pharmaceutical composition comprising polymeric microparticles including a drug and a fatty acid, which composition may be adapted to provide a release rate of drug that is approximately linear with time, and to provide no significant burst effect.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249419/
If the drug is loaded by the incorporation method, then the system has a relatively small burst effect and sustained release characteristics (Fresta et al., 1995). If the nanoparticle is coated by polymer, the release is then controlled by diffusion of the drug from the polymeric membrane.Author: Rajesh Singh, James W. Lillard, James W. Lillard
https://www.researchgate.net/publication/11828180_On_the_importance_and_mechanisms_of_burst_release_in_matrix-controlled_drug_delivery_systems
On the importance and mechanisms of burst release in matrix-controlled drug delivery systems Article · Literature Review in Journal of Controlled Release 73(2-3):121-36 · July 2001 with 705 Reads
https://www.tepha.com/platforms/drug-delivery/
Processed at lower temperatures for improved drug stability DESCRIPTION: Tepha is developing and formulating TephaFLEX® and TephELAST® materials into a number of treatment-specific constructs for local delivery as well as systemic release of small molecule drugs and biological therapeutics.
https://www.hansvanlaarhoven.nl/reservoir-system/
In this case approximately half the amount of drug dissolved in the membrane is released quickly until again steady state release is obtained. If the total amount of released drug is plotted versus time, the so-called time lag and burst effect curves are obtained.
https://engineering.lehigh.edu/research/resolve/volume-1-2008/anthony-mchugh-exploding-burst-effect
The fabrication of drug-delivery systems, a multibillion-dollar industry, is faced with two competing challenges: achieving sufficient drug load (DL) in delivery media while avoiding the socalled “burst effect.”This burst effect – in which a large drug volume is quickly released into the body – can be dangerous. Furthermore, the drugs’ expense makes it advantageous to contain
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