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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769877/
With intradermal injection or infusion of regular human insulin or a rapid-acting insulin analog, a rapid onset of action along with a meal can be achieved. 2 The aim of this review is to critically review our current knowledge about oral insulin and buccal insulin, two other quite promising developments for ARIA, with a clear focus on presenting data from clinical–experimental and clinical studies.Author: Lutz Heinemann, Yves Jacques
http://www.iptonline.com/articles/public/IPT_17_2005_p74_76.pdf
The Buccal Delivery of Insulin A system for the administration of medicines directly into the mouth for absorption by the buccal mucosa is showing promise in the oral delivery of insulin – as well as other large-molecule drugs. By Gerald Bernstein at Generex Biotechnology Corporation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787057/
BUCCAL INSULIN. Buccal delivery of insulin has similar benefits as oral insulin with the advantage of bypassing GI degradation. Furthermore, the relatively large surface area results in better bioavailability. Initially, Generex Biotechnology developed Oral-lyn™ which is a liquid formulation of short acting insulin that is administered using Generex's metered dosage aerosol applicator (RapidMist™).
https://journals.sagepub.com/doi/pdf/10.1177/193229680900300323
injections is the use of microneedles for insulin delivery. With intradermal injection or infusion of regular human insulin or a rapid-acting insulin analog, a rapid onset of action along with a meal can be achieved.2 The aim of this review is to critically review our current knowledge about oral insulin and buccal insulin, two other quite
https://www.medscape.com/viewarticle/711237
Nov 04, 2019 · Buccal spray delivers the insulin directly to the oropharyngeal mucosa, avoiding lung exposure, with peak action 10 minutes after administration.
https://sites.ualberta.ca/~csps/JPPS1(1)/A.Shojaei/buccalreview.htm
Buccal drug delivery is a promising area for continued research with the aim of systemic delivery of orally inefficient drugs as well as a feasible and attractive alternative for non-invasive delivery of potent peptide and protein drug molecules.
https://www.sciencedirect.com/science/article/pii/S135964461830254X
In this formulation, recombinant human insulin is bound to glycan-coated GNP through noncovalent binding and embedded in a polymeric mucoadhesive film for the delivery of insulin via the buccal mucosa. It is claimed by Midatech Pharm that the GNP technology helps drugs to cross membranes, leading to an increase in stability.Author: Najma Easa, Raid G. Alany, Mark Carew, Anil Vangala
http://mysticpharmaceuticals.com/sublingual-delivery/
Sublingual Delivery Systems. VersiDoser® and VRx2™ precision metered dose sublingual delivery systems are designed for non-invasive systemic delivery of drugs, proteins and peptides via sublingual or buccal mucosa. Delivery applications include pharmaceutical, bio-pharmaceutical and biologics for pain management, hormone replacement ...
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