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https://www.sciencedirect.com/science/article/pii/S0142961217307640
For bone marrow drug delivery, the drug accumulation amounts in the bone are ascribed to the uptake of particulates by phagocytic reticulo-endothelial cells of sinusoid vessels in the bone marrow . The endothelium of vascular sinusoids collects particulates from the blood circulation via both transcellular and intercellular routes.Author: Chao-Feng Mu, Jianliang Shen, Jianliang Shen, Jing Liang, Hang-Sheng Zheng, Yang Xiong, Ying-Hui Wei...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076608/
Bone marrow targeted drug delivery systems appear to offer a promising strategy for advancing diagnostic, protective, and/or therapeutic medicine for the hematopoietic system. Liposome technology can provide a drug delivery system with high bone marrow targeting that is mediated by specific phagocytosis in bone marrow.Author: Keitaro Sou, Beth Goins, Babatunde O. Oyajobi, Bruno L. Travi, William T. Phillips
https://medicalxpress.com/news/2018-10-delivery-drugs-cancer-cells-bone.html
Oct 30, 2018 · Researchers design delivery system to guide drugs directly to cancer cells 'hiding' in bone marrow. by Matthew Chin, University of California, Los Angeles
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278842/
Liposomal drug delivery can improve the therapeutic index of treatments for multiple myeloma. However, an appropriate 3D model for the in vitro evaluation of liposomal drug delivery is lacking. In this study, we applied a previously developed 3D bone marrow (BM) myeloma model to …Author: Maaike V.J. Braham, Anil K. Deshantri, Monique C. Minnema, F. Cumhur Öner, Raymond M. Schiffelers, M...
https://pharm.ucsf.edu/desai/research/osteomyelitis
Bone drug delivery. Osteomyelitis is a bone or bone marrow infection that requires prolonged antibiotic therapy and surgical debridement. We are developing nanoparticles that both release a therapeutic payload and restructure damaged bone.
https://www.researchgate.net/publication/299979500_DRUG_DELIVERY_TO_BRAIN_AND_BONE_MARROW_A_REVIEW
drug delivery to brain and bone marrow: a review Rahul Saikia, Ashis Kumar Goswami and Hemanta Kumar Sharma* Department of Pharmaceutical Sciences, Dibrugarh Universit y, …
https://digitalcommons.library.tmc.edu/utgsbs_dissertations/158/
Bone marrow is a target organ site involved in multiple diseases including myeloproliferative disorders and hematologic malignancies and metastases from breast and prostate. Most of these diseases are characterized with poor quality of life, and the treatment options are only palliative due to lack of delivery mechanisms for systemically injected drugs which results in dose limitation to ...Author: Aman Mann
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