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https://onlinelibrary.wiley.com/doi/10.1002/9781118747896.ch6
Block copolymer amphiphiles self‐assemble in aqueous solutions into micelles and vesicles. This chapter reviews the biological challenges and opportunities associated with block copolymer drug delivery vehicles and outlines their successes in the delivery of drugs and nucleic acids in vitro and in vivo. It focuses on block copolymer micelles and polymersomes, the properties of which make them desirable drug carriers and successful in delivering drug …Author: James D. Robertson, Nisa Patikarnmonthon, Adrian S. Joseph, Giuseppe Battaglia
https://www.sciencedirect.com/science/article/abs/pii/S0169409X12002736
Block copolymer micelles for drug delivery: Design, ... and hydrogen bonding of constituent block copolymers. The segregated core embedded in the hydrophilic palisade is shown to function as a reservoir for genes, enzymes, and a variety of drugs with diverse characteristics. Functionalization of the outer surface of the polymeric micelle to ...Author: Kazunori Kataoka, Atsushi Harada, Yukio Nagasaki
https://www.sciencedirect.com/science/article/pii/S0168365905004906
Block copolymer micelles: preparation, characterization and application in drug delivery 1. Introduction. 2. Polymeric micelles: composition and structure. 3. Polymer synthesis. 4. Micelle preparation. 5. Micellar drug solubilization. 6. Micelle stability. 7. Long circulating properties. 8. ...Author: Geneviève Gaucher, Marie-Hélène Dufresne, Vinayak P. Sant, Ning Kang, Dusica Maysinger, Jean-Christo...
https://www.rug.nl/research/zernike/education/topmasternanoscience/ns190solmaz.pdf
Amphiphilic block copolymer micelles have been the focus of research for the last decades because of the promising properties as nano size drug delivery vehicles. In polar aqueous milieu, copolymers self assemble into micelle structures which consist of hydrophilic corona and hydrophobic core regions.
https://www.ncbi.nlm.nih.gov/pubmed/11251249
Mar 23, 2001 · Block copolymer micelles for drug delivery: design, characterization and biological significance. Kataoka K(1), Harada A, Nagasaki Y. Author information: (1)Department of Materials Science, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. [email protected]: Kazunori Kataoka, Atsushi Harada, Yukio Nagasaki
https://www.sciencedirect.com/science/article/pii/0168365993901722
There is a wide-spread consensus that characteristics of drug vehicles determine the applicability of the site-specific delivery of drugs. This article focused on the promising features of block copolymer micelles as drug vehicles mimicking the natural carrier-systems with supramolecular structures (i.e. viruses and lipoproteins).Author: Kataoka Kazunori, S Kwon Glenn, Yokoyama Masayuki, Okano Teruo, Sakurai Yasuhisa
https://pubs.rsc.org/en/content/articlelanding/2020/bm/c9bm02036e
Because of their excellent capacity to significantly improve the bioavailability and solubility of chemotherapy drugs, block copolymer micelles are widely utilized for chemotherapy drug delivery. In order to further improve the anti-tumor ability and reduce …
https://www.sciencedirect.com/science/article/pii/0169409X95000312
The development of block copolymer micelles as long-circulating drug vehicles is described. As well, a recent fundamental study of block copolymer micelles, where much insight into their structures and properties has been realized, is briefly summarized in order to shed light on their properties in vivo.Author: Glen S. Kwon, Kazunori Kataoka
https://www.ncbi.nlm.nih.gov/pubmed/17168771
Author information: (1)School of Pharmacy, University of Wisconsin, Madison, Wisconsin, USA. Polymeric micelles are nanoscopic core/shell structures formed by amphiphilic block copolymers. Both the inherent and modifiable properties of polymeric micelles make them particularly well suited for drug delivery purposes.Author: S. R. Croy, G. S. Kwon
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