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https://www.sciencedirect.com/science/article/pii/0168365993901722
There is a wide-spread consensus that characteristics of drug vehicles determine the applicability of the site-specific delivery of drugs. This article focused on the promising features of block copolymer micelles as drug vehicles mimicking the natural carrier-systems …Author: Kataoka Kazunori, S Kwon Glenn, Yokoyama Masayuki, Okano Teruo, Sakurai Yasuhisa
https://www.sciencedirect.com/science/article/pii/0169409X95000312
The development of block copolymer micelles as long-circulating drug vehicles is described. As well, a recent fundamental study of block copolymer micelles, where much insight into their structures and properties has been realized, is briefly summarized in order to shed light on their properties in vivo.Author: Glen S. Kwon, Kazunori Kataoka
https://www.rug.nl/research/zernike/education/topmasternanoscience/ns190solmaz.pdf
Amphiphilic block copolymer micelles for drug delivery applications are significant mainly in two aspects. First of all, hydrophobic drug molecules can be loaded to the micelle core to be carried to the target with a higher solubility than its intrinsic solubility in bloodstream which shows hydrophilic properties.
https://pubs.acs.org/doi/10.1021/bm0508921
The excellent potential of these pH-responsive micelles as nanosized drug delivery vehicles was illustrated by the encapsulation of dipyridamole (DIP), a model hydrophobic drug that dissolves in acid solutions and becomes insoluble above pH 5.8, which is comparable to the pKa of …Author: Cristiano Giacomelli, Lucile Le Men, Redouane Borsali, Joséphine Lai-Kee-Him, Alain Brisson, Steven ...
https://onlinelibrary.wiley.com/doi/10.1002/9781118747896.ch6
Block copolymer amphiphiles self‐assemble in aqueous solutions into micelles and vesicles. This chapter reviews the biological challenges and opportunities associated with block copolymer drug delivery vehicles and outlines their successes in the delivery of drugs and nucleic acids in vitro and in vivo.It focuses on block copolymer micelles and polymersomes, the properties of which make them ...Author: James D. Robertson, Nisa Patikarnmonthon, Adrian S. Joseph, Giuseppe Battaglia
https://www.ncbi.nlm.nih.gov/pubmed/17168771
Polymeric micelles are nanoscopic core/shell structures formed by amphiphilic block copolymers. Both the inherent and modifiable properties of polymeric micelles make them particularly well suited for drug delivery purposes.Author: S. R. Croy, G. S. Kwon
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