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https://www.sciencedirect.com/science/article/pii/016158909190076V
Anti-SEB toxin antibodies of the IgG isotype in the plasma were determined by end-point titration in a RIA. Biodegradable microspheres as a vaccine delivery system 291 antigenic materials from the gut lumen and transport them to the underlying lymphoreticular cells.Author: John H. Eldridge, Jay K. Staas, Jonathan A. Meulbroek, Jerry R. McGhee, Thomas R. Tice, Richard M. G...
https://www.ncbi.nlm.nih.gov/pubmed/2017198
Biodegradable microspheres as a vaccine delivery system. Eldridge JH(1), Staas JK, Meulbroek JA, McGhee JR, Tice TR, Gilley RM. Author information: (1)Department of Microbiology, University of Alabama, Birmingham 35294.Author: John H. Eldridge, Jay K. Staas, Jonathan A. Meulbroek, Jerry R. McGhee, Thomas R. Tice, Richard M. G...
https://www.sciencedirect.com/science/article/pii/S0168365903001949
Despite considerable research efforts and impressive progress made in recent years, the question of feasibility of injectable biodegradable microspheres as protein or vaccine delivery system remains open to debate. Presently only a countable number of formulations based on …Author: V.R. Sinha, Aman Trehan
https://www.sciencedaily.com/releases/2007/02/070228170345.htm
A new vaccine delivery system using microspheres of a biodegradable polymer may not only reduce the need for booster shots in some cases, but also appears to stimulate an immune response that ...
https://link.springer.com/chapter/10.1007%2F978-3-642-74529-4_6
Abstract. The potential of biocompatible and biodegradable microspheres as a controlled release oral vaccine delivery system has been examined. Orally-administered 1–10 μm microspheres composed of poly (DL-lactide-co-glycolide) were specifically taken up into the Peyer’s patch lymphoid tissue of the gut, where those ≥ 5 μm remained for up to 35 days.Author: J. H. Eldridge, R. M. Gilley, J. K. Staas, Z. Moldoveanu, J. A. Meulbroek, T. R. Tice
https://www.researchgate.net/publication/299126177_Biodegradable_polymer_microspheres_as_vaccine_adjuvants_and_delivery_systems
Biodegradable polymer microspheres as vaccine adjuvants and delivery systems ... Nanotechnology based vaccine delivery system is an innovation of the 21st century (Panyam and Labhasetwar, 2003 ...
https://www.researchgate.net/publication/51342903_Biodegradable_polymer_microspheres_as_vaccine_adjuvants_and_delivery_systems
The use of biodegradable polymer microspheres as a single dose vaccine delivery system was investigated by using tetanus toxoid (TT). ... Biodegradable …
http://microspheres.us/drug_delivery/motivations-biodegradable-microspheres-drug-delivery/187.html
Use of biodegradable polymers minimizes the possibility of toxicity problems, but does produce by-products that must be tolerated without adverse reactions. According to the Polymeric Drug Delivery – A Brief Review, the three key advantages that polymeric drug delivery products can offer are:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465129/
Vaccine delivery systems can be classified as follows. Solid particulates: Solid particulate systems such as microspheres and lipospheres are being exploited for vaccine delivery [Table 1] based on the fact that intestine is an imperfect barrier to small particulates. Antigens entrapped in such particulates when taken up by M-cells can generate ...
http://europepmc.org/abstract/MED/2731430
Jan 01, 1989 · The potential of biocompatible and biodegradable microspheres as a controlled release oral vaccine delivery system has been examined. Orally-administered 1-10 micron microspheres composed of poly (DL-lactide-co-glycolide) were specifically taken up into the Peyer's patch lymphoid tissue of the gut, where those greater than or equal to 5 micron remained for up to 35 days.Author: J. H. Eldridge, R. M. Gilley, J. K. Staas, Z. Moldoveanu, J. A. Meulbroek, T. R. Tice
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