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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106925/
Jul 22, 2014 · The complexity of the in vivo system thus inflicts multiple biological barriers which impedes NP drug delivery to solid tumors. In current anti-cancer therapies, NPs are generally administered intravenously (IV). This route is fast, reliable and allows complete distribution via the systemic circulation.Author: Shravan Kumar Sriraman, Bhawani Aryasomayajula, Vladimir P Torchilin
https://www.tandfonline.com/doi/pdf/10.4161/tisb.29528
biological barriers which impedes NP drug delivery to solid tumors.2 In current anti-cancer therapies, NPs are generally administered intravenously (IV). This route is fast, reliable and allows complete distribution via the systemic circulation. Once in circulation, the NPs face a …
https://www.jstor.org/stable/24942767
Barriers to Drug Delivery in Solid Tumors Many tumors resist full penetration by anticancer agents. Such resistance may help explain why drugs that eradicate tumor cells in laboratory dishes often fail to eliminate malignancies in the body by Rakesh K. Jain IDEALIZED SOLID TUMOR has been part-ly cut away to reveal some of its blood vessels.
https://www.researchgate.net/publication/264396079_Barriers_to_drug_delivery_in_solid_tumors
The advent of engineered nanoparticles has allowed us to circumvent the initial limitations to drug delivery such as pharmacokinetics and solubility. However, in spite of significant advances to...
https://www.tandfonline.com/doi/abs/10.4161/tisb.29528
Dec 27, 2017 · The advent of engineered nanoparticles has allowed us to circumvent the initial limitations to drug delivery such as pharmacokinetics and solubility. However, in spite of significant advances to tumor targeting, an effective treatment strategy for malignant tumors …Author: Shravan Kumar Sriraman, Bhawani Aryasomayajula, Vladimir P Torchilin
http://europepmc.org/articles/PMC4106925
Dec 01, 2013 · In order to arrive at the appropriate solutions we must first seek to identify and understand the problems. The complexity of the in vivo system thus inflicts multiple biological barriers which impedes NP drug delivery to solid tumors. 2 In current anti-cancer therapies, NPs are generally administered intravenously (IV). This route is fast, reliable and allows complete distribution via the systemic circulation.
https://www.ncbi.nlm.nih.gov/pubmed/28917530
Dec 10, 2017 · We also discuss specific obstacles to drug delivery that make solid tumors difficult to treat, as well strategies to overcome them and enhance drug penetration. Finally, we describe the caveolae pumping system, a promising active transport alternative to passive drug delivery across the endothelial cell barrier.Author: Susy M. Kim, Peggy H. Faix, Jan E. Schnitzer
https://www.sciencedirect.com/science/article/pii/S0168365914008153
The penetration barriers in tumor tissue that limit drug delivery are associated with patho-physiological components of the solid tumor microenvironment, which include abnormal and poorly perfused vasculature and avascular area of tumors with little convection, either due to overproduction of immature vessels or intra-tumoral pressure (“solid stress” as described below) applied on tumor vasculature …Author: Iftikhar Ali Khawar, Jung Ho Kim, Hyo-Jeong Kuh
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