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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106925/
Jul 22, 2014 · The complexity of the in vivo system thus inflicts multiple biological barriers which impedes NP drug delivery to solid tumors. In current anti-cancer therapies, NPs are generally administered intravenously (IV). This route is fast, reliable and allows complete distribution via the systemic circulation.Author: Shravan Kumar Sriraman, Bhawani Aryasomayajula, Vladimir P Torchilin
https://www.jstor.org/stable/24942767
Barriers to Drug Delivery in Solid Tumors Many tumors resist full penetration by anticancer agents. Such resistance may help explain why drugs that eradicate tumor cells in laboratory dishes often fail to eliminate malignancies in the body by Rakesh K. Jain IDEALIZED SOLID TUMOR has been part-ly cut away to reveal some of its blood vessels.
https://clincancerres.aacrjournals.org/content/5/7/1605
Jul 01, 1999 · There are at least four known physiological barriers to delivery of a blood-borne agent. The first barrier is the heterogeneous angiogenesis and blood flow in tumors. The second barrier is the heterogeneous permeability of tumor vessels. Tumor vessels are generally hyperpermeable, supporting the use of high MW therapeutic agents .Author: Rakesh K. Jain
https://www.tandfonline.com/doi/pdf/10.4161/tisb.29528
biological barriers which impedes NP drug delivery to solid tumors.2 In current anti-cancer therapies, NPs are generally administered intravenously (IV). This route is fast, reliable and allows complete distribution via the systemic circulation. Once in circulation, the NPs face a …
https://www.sciencedirect.com/science/article/pii/104084289390004N
Conclusions The chaotic nature of tumor blood vessels and blood flow, the varied composition of the tumor interstitium and disturbed convection and diffusion in the interstitial space of tumors all create significant potential physical barriers to the delivery of therapeutic agents to neoplastic cells in vivo.Author: Brendan D. Curti
https://www.sciencedirect.com/science/article/pii/S0168365914008153
The penetration barriers in tumor tissue that limit drug delivery are associated with patho-physiological components of the solid tumor microenvironment, which include abnormal and poorly perfused vasculature and avascular area of tumors with little convection, either due to overproduction of immature vessels or intra-tumoral pressure (“solid stress” as described below) applied on tumor vasculature and the parenchymal tissue .Author: Iftikhar Ali Khawar, Jung Ho Kim, Hyo-Jeong Kuh
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