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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218254/
Aptamers for drug delivery The emerging integration of aptamers with nanotechnology and chemical biology is envisioned to produce more versatile target-specific molecules, stimulate further new diagnostic and therapeutic nanotechnologies, and provide significant potential for many research and clinical applications in the near future.Author: Weihong Tan, Weihong Tan, Hui Wang, Yan Chen, Yan Chen, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoy...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033951/
In the study conducted by Tong et al. , the sgc8c aptamer was conjugated to the surface of a viral capsid protein (MS2) by using chemoselective oxidative coupling reaction to construct a biodegradable drug-delivery vehicle. The interior of the viral capsid was modified and linked to the AlexaFluor 488 maleimide in order to detect it in cell-binding assays.Author: Partha Ray, Rebekah R. White
https://www.basepairbio.com/drug-discovery-development/
Aptamer-drug conjugates can be used to deliver drugs to target cells and offer several advantages over antibody-drug conjugates. Directed delivery of drug compounds limits off-target effects. Increased delivery to target cells can lower the required dosage and improve efficacy.
https://www.oligotherapeutics.org/targeted-delivery-using-aptamers/
He gained his PhD in the development of aptamer nanocarriers as tools for targeted drug delivery from the Scuola Normale Superiore, Pisa, Italy, in 2016 and …
https://tan.chem.ufl.edu/wp-content/uploads/sites/39/pubs/important-articles/Molecular%20aptamers%20for%20drug%20delivery.pdf
in aptamer-mediated delivery for therapeutics and disease-targeting based on aptamer integration with a variety of nanomaterials, such as gold nanorods, DNA micelles, DNA hydrogels and carbon nanotubes. Introduction Aptamers are single-stranded (ss) oligonucleotides that can bind to their target molecules with high affinity and selectivity
https://www.sciencedirect.com/science/article/pii/S0169409X18302473
Aptamers can be used as guiding molecules for the delivery of drugs and various macromolecules or nanocarriers to tumor cells. Therefore, several RNA and DNA aptamers have been successfully selected against potential cancer cell surface receptors.Author: Walhan Alshaer, Walhan Alshaer, Hervé Hillaireau, Elias Fattal
https://www.slideshare.net/AnuragPandey60/aptamers-based-drug-delivery-93903621
Apr 15, 2018 · Aptamers for Targeted Drug Delivery, Partha Ray and Rebekah R. White & Department of Surgery, Duke University Medical Center, DUMC Box 103035, Durham, NC 27710, USA 2. Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems, Feng Jiang, International Journal of Molecular Sciences ISSN 1422-0067 3.
https://www.sciencedirect.com/science/article/pii/S0167779911001132
The cell membrane is basically a dynamic lipid bilayer; therefore, this liposome nanostructure can efficiently increase cell permeability and enhance drug delivery. A cell-permeable sgc8–PEG–liposome nanostructure has also been reported for drug delivery . With approximately 250 aptamers on each liposome, this design leads to multiple aptamer–receptor interactions, provides better binding to the …Author: Weihong Tan, Weihong Tan, Hui Wang, Yan Chen, Yan Chen, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoy...
https://www.nature.com/articles/nrd.2016.199
Nov 03, 2016 · Aptamer-based therapeutics typically exploit one of three strategies: an aptamer can serve as an antagonist for blocking the interaction of disease-associated targets (for example, receptor–ligand interactions); an aptamer can serve as an agonist for activating the function of target receptors; or a cell-type-specific aptamer can serve as...Author: Jiehua Zhou, John Rossi
https://pubs.acs.org/doi/10.1021/nn901374b
Aptamer-Based Tumor-Targeted Drug Delivery for Photodynamic Therapy ACS Nano A specialized G-rich DNA structure, G-quadruplex, has been studied for its special physical characteristics and biological effects. Herein we report a novel strategy of using G-quadruplex as a drug carrier to target cancer cells for photodynamic therapy (PDT).Author: Yen-An Shieh, Shu-Jyuan Yang, Ming-Feng Wei, Ming-Jium Shieh
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