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https://www.sciencedirect.com/science/article/pii/S0169409X00000806
Oct 31, 2000 · Oral delivery The term ‘Antisense Therapeutics’ or ‘Antisense Technology’ encompasses several types of nucleic acids that have the ability to modulate gene expression. The most common types of nucleic acids included in this term are antisense oligonucleotides (ODNs), ribozymes (RNA enzymes) and more recently, DNAzymes (DNA enzymes).Author: Saghir Akhtar, Marcus D. Hughes, Marcus D. Hughes, Alim Khan, Alim Khan, Mike Bibby, Majad Hussain, ...
https://www.sciencedirect.com/science/article/abs/pii/0169409X9500006S
In summary, this review discusses different approaches for delivery of antisense oligonucleotides to the brain and suggests that biotinylated PNA conjugated to avidin-based transcellular delivery system represents a model for the delivery of antisense therapeutics through the blood-brain barrier.Author: Ruben J. Boado
https://www.ncbi.nlm.nih.gov/pubmed/11035194
Oct 31, 2000 · The first antisense drug molecule is now available for clinical use in Europe and USA. However, their successful application in the clinic will require improvements in cellular targeting and intracellular delivery. This review aims to look at recent advances in the in vitro and in vivo delivery of antisense oligodeoxynucleotides and ribozymes.Author: Saghir Akhtar, Marcus D. Hughes, Marcus D. Hughes, Alim Khan, Alim Khan, Mike Bibby, Majad Hussain, ...
https://www.grandviewresearch.com/industry-analysis/global-antisense-and-rni-therapeutic-market
Drug delivery to the nervous tissues is one of the problems as the drug has to pass the blood-brain barrier. Companies are coming up with solutions to overcome these challenges. The toxic effects caused is another challenge for the use of this technology. Determining the right dosage and vector for drug delivery of an antisense molecule is one of the most important steps to ensure the safe administration.
https://www.ionispharma.com/ionis-innovation/antisense-technology/
on antisense drug The Ionis antisense advantage Optimizing antisense through advancements in medicinal chemistry and pioneering new ways to deliver antisense has been a central focus of our research efforts, allowing us to bring options to those who have had none.
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