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https://www.sciencedirect.com/science/article/abs/pii/0169409X9500006S
The blood-brain barrier evolved to protect the brain against peripheral neurotransmitters, cytotoxins and microorganisms. This barrier prevents the delivery to brain of antisense oligomers and other potential therapeutics for the treatment of viral infections, tumors, and other brain disorders.Author: Ruben J. Boado
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201914751
Jan 29, 2020 · Systemic Brain Delivery of Antisense Oligonucleotides across the Blood–Brain Barrier with a Glucose‐Coated Polymeric Nanocarrier Dr. Hyun Su Min Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656 JapanAuthor: Hyun Su Min, Hyun Jin Kim, Mitsuru Naito, Satomi Ogura, Kazuko Toh, Kotaro Hayashi, Beob Soo Kim, Sh...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588205/
Sep 21, 2015 · The blood–brain barrier (BBB) is a major obstacle that prevents therapeutic drugs or genes from being delivered to the central nervous system. Therefore, it is important to develop methods to enhance the permeability of the BBB.Author: Yoichi Negishi, Masaya Yamane, Naho Kurihara, Yoko Endo-Takahashi, Sanae Sashida, Norio Takagi, Ryo ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494002/
Aug 29, 2012 · In contrast, diffusion plays no role in the transvascular route of drug delivery to the brain. The distance between capillaries in brain is about 40 μ m ( Figure 1C ). Even a large molecule antibody drug diffuses 40 μ m within a second. Therefore, once a drug is delivered across the BBB from blood…Author: William M Pardridge
https://www.sciencedirect.com/journal/advanced-drug-delivery-reviews/vol/15/issue/1
Read the latest articles of Advanced Drug Delivery Reviews at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
https://www.nature.com/articles/nrd.2015.21
Jan 22, 2016 · From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery William A. Banks 1 Nature Reviews Drug Discovery volume 15 , pages 275 – 292 ( …Author: William A. Banks
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC539316/
Therefore, the lipidized form of the drug is rapidly removed from the blood, and in pharmacokinetic terms, the plasma area under the concentration curve (AUC) is substantially decreased for the lipidized form of the drug. Drug action in brain is a function of drug uptake, expressed as percent of …
https://www.sciencedirect.com/science/article/pii/S0169409X11002900
5.2. Transport system-mediated drug delivery across the blood–brain barrier. The combination of endogenous transport systems present in the BBB and macromolecular conjugates or surface enhanced nano-particulate delivery systems such as liposomes, nanoparticles and supermolecular complexes has been utilised to access the brain.Author: Yan Chen, Lihong Liu
https://www.sciencedirect.com/science/article/pii/S0169409X15000435
In drug discovery, the aim is to find a substance which is potent, selective, and preferably bioavailable that needs to reach its target at sufficient concentrations .For drugs to reach the nervous system they first have to cross the vascular barrier, which is made up of the blood brain barrier (BBB) or the blood–spinal cord barrier (BSCB).Author: Melvin M. Evers, Lodewijk J.A. Toonen, Willeke M.C. van Roon-Mom
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