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https://pubs.acs.org/doi/10.1021/jacs.9b09043
Precisely assembled DNA nanostructures are promising candidates for the delivery of biomolecule-based therapeutics. Herein, we introduce a facile strategy for the construction of a branched DNA-based nanoplatform for codelivery of gene editing (sgRNA/Cas9, targeting DNA in the nucleus) and gene silencing (antisense, targeting mRNA in the cytoplasm) components for synergistic tumor therapy in ...Author: Jianbing Liu, Tiantian Wu, Tiantian Wu, Xuehe Lu, Xuehe Lu, Xiaohui Wu, Xiaohui Wu, Shaoli Liu, Shao...
https://www.nature.com/articles/nrneurol.2017.148
Dec 01, 2017 · Falzarano, M. S., Passarelli, C. & Ferlini, A. Nanoparticle delivery of antisense oligonucleotides and their application in the exon skipping strategy for Duchenne muscular dystrophy.Author: C Rinaldi, Wood Mja.
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201914751
Jan 29, 2020 · Systemic Brain Delivery of Antisense Oligonucleotides across the Blood–Brain Barrier with a Glucose‐Coated Polymeric Nanocarrier. Dr. Hyun Su Min. Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, …Author: Hyun Su Min, Hyun Jin Kim, Mitsuru Naito, Satomi Ogura, Kazuko Toh, Kotaro Hayashi, Beob Soo Kim, Sh...
https://www.sciencedirect.com/science/article/pii/S0169409X15000435
In rats, intranasal delivery of antisense oligonucleotides was found to lead to good distribution throughout the brain, and was able to slow down intracerebral tumour growth . These studies hence indicate that intranasal delivery may become a viable option for antisense oligonucleotide delivery in the future. 3. Chemical modificationsAuthor: Melvin M. Evers, Lodewijk J.A. Toonen, Willeke M.C. van Roon-Mom
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975145/
Aug 01, 2016 · The application of antisense inhibition to bacterial cells is an attractive alternative to conventional antibiotics but presents a particular challenge in requiring efficient delivery of antisense molecules across bacterial cell envelopes.Author: John P Hegarty, Jacek Krzeminski, Arun K Sharma, Diana Guzman-Villanueva, Volkmar Weissig, David B S...
https://www.ncbi.nlm.nih.gov/pubmed/22862291
Sep 25, 2012 · Gene silencing by gold nanoshell-mediated delivery and laser-triggered release of antisense oligonucleotide and siRNA. Huschka R(1), Barhoumi A, Liu Q, Roth JA, Ji L, Halas NJ. Author information: (1)Department of Chemistry, Rice University, …Author: Ryan Huschka, Aoune Barhoumi, Qing Liu, Jack A. Roth, Lin Ji, Naomi J. Halas
The Delivery of Antisense RNA ThERapeutics (DARTER) Action Members is a highly dedicated group of scientists, whose goal is (through COST networking tools) to allow RNA-targeting nucleic acid drugs to reach their full potential and become a mainstream therapeutic option. Antisense oligonucleotides (ASOs) are a new class of drugs that, through very specific targeting, could correct genetic ...
https://www.proqr.com/wp-content/uploads/downloads/2017/09/ProQR_QR-313_Local-delivery.pdf
Local delivery of an antisense oligonucleotide for recessive dystrophic epidermolysis bullosa R Mendes, L van Wissen, MW de Jager, F van der Ham, V Brinks, T Ritsema, EM Haisma ProQR Therapeutics N.V. Leiden, the Netherlands Results (continued) Next delivery …
https://www.sciencedirect.com/science/article/pii/S2162253120300536
The efficient delivery of antisense oligonucleotides (ASOs) to the targeted cells and organs remains a challenge, in particular, in vivo.Here, we investigated the ability of a library of biodegradable lipid nanoparticles (LNPs) in delivering ASO to both cultured human cells and animal models.Author: Liu Yang, Feihe Ma, Fang Liu, Jinjin Chen, Xuewei Zhao, Qiaobing Xu
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