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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534807/
Aug 12, 2015 · A major hurdle of developing successful and effective vaccines is to design antigen delivery systems in such a way that optimizes antigen presentation and induces broad protective immune responses. Recent advances in vector delivery technologies, immunology, vaccinology and system biology, have led to a deeper understanding of the molecular and ...Author: Maria Trovato, Piergiuseppe De Berardinis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465129/
VACCINE DELIVERY SYSTEMS. Delivery of antigens from oil-based adjuvants such as Freunds[] adjuvant lead to a reduction in the number of doses of vaccine to be administered but due to toxicity concerns like inductions of granulomas at the injection site, such adjuvants are not widely used.FDA approved adjuvants for human uses are aluminium hydroxide and aluminium phosphate in the form of …
https://www.immunology.org/public-information/bitesized-immunology/vaccines-and-therapeutics/adjuvants-particulate-antigen
Adjuvants: particulate antigen delivery systems. Download A.ppt (561.5 KB) Download Adjuvants - particulate delivery systems (Adyuvan.pdf (215.14 KB) Rebecca Helson, London, UK . MF59 is an oil-in-water emulsion appearing as small, uniform oil droplets and has shown great promise as a vaccine against influenza for the elderly. Safety and ...
https://www.sciencedirect.com/science/article/pii/S0142961215006134
Delivery systems of various kinds including virus-based particles, polymeric nanoparticles, nanogels, and liposomes reportedly achieve cytoplasmic delivery of exogenous antigens into DCs and induction of immune responses , , , , , , , , .Among them, pH-sensitive liposomes might be of particular importance because of their ability to deliver contents into cytosol via membrane fusion with ...Author: Eiji Yuba, Yuhei Kanda, Yuta Yoshizaki, Ryoma Teranishi, Atsushi Harada, Kikuya Sugiura, Takeshi Iza...
https://www.researchgate.net/publication/279972272_Antigen_Delivery_Systems_I
This chapter reviews the non-replicating antigen delivery systems, including microparticles, liposomes, and immune-stimulating complexes (ISCOMs), which are very useful in vaccine development.
https://www.sciencedirect.com/science/article/pii/S0142961212014111
Efficient delivery of antigen into cytosol of DCs is a key factor for efficient antigen presentation on MHC class I molecules . Therefore, to engender antigen presentation via MHC class I pathway efficiently, carrier systems should have functions that promote the transfer of antigen from endosome and/or lysosome into cytosol of DCs.Author: Eiji Yuba, Atsushi Harada, Yuichi Sakanishi, Shinobu Watarai, Kenji Kono
https://www.researchgate.net/publication/8438300_Antigen_delivery_systems
Hence, the use of particulate delivery systems as carriers for antigen and/or immunostimulatory adjuvants for effective delivery to the antigen-presenting cells (APCs) is a valuable strategy to ...
https://advances.sciencemag.org/content/5/10/eaaw6870.full
Oct 01, 2019 · Over the past few decades, various antigen delivery systems have been reported in animal models. Micro-/nanoformulations and macroscale biomaterials as effective antigen delivery tools and/or as adjuvants for improving immune response could generate robust antitumor immune response compared with free antigen (16, 21–27). However, many of them ...Author: Xiao Han, Shufang Shen, Qin Fan, Guojun Chen, Edikan Archibong, Gianpietro Dotti, Zhuang Liu, Zhen G...
https://www.hindawi.com/journals/jir/2015/960859/
In finfish, different antigen delivery systems have been explored that include live, DNA, inactivated whole virus, fusion protein, virus-like particles, and subunit vaccines although mechanisms linking these delivery systems to protective immunity have not been studied in detail.Author: Hetron Mweemba Munang’andu, Øystein Evensen
https://www.mdpi.com/2076-393X/4/4/48/htm
Furthermore, as shown herein, current vaccine designs include the use of replicative antigen delivery systems, such as attenuated virulent strains, heterologous vectors and DNA vaccines, while non-replicative vaccines include the inactivated whole cell (IWC) and subunit vaccines encoding different S. agalactiae immunogenic proteins.Author: Hetron Mweemba Munang’andu, Joydeb Paul, Øystein Evensen
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