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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534807/
Aug 12, 2015 · The E2 protein scaffold represents a versatile antigen delivery system (E2DISP) where antigenic determinants can be exposed on the surface of an icosahedral dodecahedral nanoparticle[61,62]. The scaffold is composed of the E2 acetyltransferase protein derived from the pyruvate dehydrogenase ...Author: Maria Trovato, Piergiuseppe De Berardinis
https://www.sciencedirect.com/science/article/pii/S016836591930118X
Another approach has been described in which 200 nm antigen loaded ZIF-8 was prepared in methanol solutions by using ultrasonication with the help of polyvinyl pyrrolidone (PVP) . In contrast to our system, this antigen delivery platform induced strong humoral but weak cellular immune response.Author: Xiaofang Zhong, Yunting Zhang, Lu Tan, Tao Zheng, Yingying Hou, Xiaoyu Hong, Guangsheng Du, Xiaoyan ...
https://www.immunology.org/public-information/bitesized-immunology/vaccines-and-therapeutics/adjuvants-particulate-antigen
Adjuvants: particulate antigen delivery systems. Download A.ppt (561.5 KB) Download Adjuvants - particulate delivery systems (Adyuvan.pdf (215.14 KB) Rebecca Helson, London, UK . MF59 is an oil-in-water emulsion appearing as small, uniform oil droplets and has shown great promise as a vaccine against influenza for the elderly. Safety and ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693225/
2. Nanoparticles in Antigen Delivery. The major advantage of using particulated antigens in vaccine formulations stems from the fact that efficient antigen presentation and induction of protective immunity require antigen uptake by specialized antigen-presenting cells (APCs).Author: Diana Boraschi, Paola Italiani
https://www.sciencedirect.com/science/article/pii/S0142961212014111
Therefore, it is crucial to use a carrier system that delivers antigen into the cytosol of DCs for induction of effective cellular immunity, which exhibits an effective tumor-suppressive effect. To date, antigen delivery systems of various types have been produced using nanoparticles for induction of antigen-specific CTLs.Author: Eiji Yuba, Atsushi Harada, Yuichi Sakanishi, Shinobu Watarai, Kenji Kono
https://advances.sciencemag.org/content/5/10/eaaw6870.full
Oct 01, 2019 · Erythrocytes or red blood cells (RBCs) represent a promising cell-mediated drug delivery platform due to their inherent biocompatibility. Here, we developed an antigen delivery system based on the nanoerythrosomes derived from RBCs, inspired by the splenic antigen-presenting cell targeting capacity of senescent RBCs. Tumor antigens were loaded onto the nanoerythrosomes by fusing …Author: Xiao Han, Shufang Shen, Qin Fan, Guojun Chen, Edikan Archibong, Gianpietro Dotti, Zhuang Liu, Zhen G...
https://www.researchgate.net/publication/279972272_Antigen_Delivery_Systems_I
This chapter reviews the non-replicating antigen delivery systems, including microparticles, liposomes, and immune-stimulating complexes (ISCOMs), which are very useful in vaccine development.
https://patents.google.com/patent/US6514503B1/en
Adjuvants for administration, particularly for mucosal administration, of an antigen, are described, as well as compositions comprising the described adjuvant in combination with an antigen and a physiologicially acceptable vehicle. Methods of eliciting and enhancing an immune response utilizing the adjuvant compositions of the invention are also described.Author: Sveinbjörn Gizurarson, Vera Gudmundsdottir
https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.201800335
Jun 19, 2018 · Importantly, it is demonstrated that the selection of the appropriate end‐oligopeptide modifications enables the specific targeting and major transfection of antigen‐presenting cells (APC) in vivo, after intravenous administration, thus enabling their use for immunotherapy strategies.Author: Cristina Fornaguera, Marta Guerra‐Rebollo, Marta Guerra‐Rebollo, Miguel Ángel Lázaro, Cristina Caste...
https://portal.nifa.usda.gov/web/crisprojectpages/0215050-antigen-delivery-system-for-elicitation-of-protective-immunity-against-johnes-disease.html
Aug 14, 2011 · We propose to develop an antigen delivery system for MAP antigens by exploiting the type III secretion system and SopE1-104 of attenuated Salmonella enterica serovar Typhimurium (S. Typhimurium) strain. This system is of particular interest as it …
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