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https://drug-dev.com/protein-therapeutics-market-technology-advances-spur-market-growth-of-protein-therapies/
Growth in the protein therapeutic market is likely to mirror these advances in manufacturing technologies. The high cost of protein therapeutics is a major challenge. High product prices result in the unavailability of certain therapies that are required by patients for quick and effective recovery.
http://www.pharmtech.com/advances-delivering-protein-and-peptide-therapeutics
Nov 02, 2016 · Despite their market growth, delivering protein and peptide drugs to the targeted site within the therapeutic range remains a significant challenge to the biopharmaceutical industry. Protein and peptide therapeutics have much higher molecular weights (MWs) than small-molecule drugs, which hinders their absorption through epithelial cells.
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0450-0
Jun 27, 2017 · Over the past few decades, RNA drugs have emerged as candidates to address diseases at the gene and RNA levels. Although it has been known since 1990 that nucleic acids can be used to modulate protein production in vivo , therapeutic RNA delivery has been limited by a number ofAuthor: James C. Kaczmarek, Piotr S. Kowalski, Daniel G. Anderson
https://www.researchgate.net/publication/274458143_Development_of_therapeutic_proteins_Advances_and_challenges
Development of therapeutic proteins: Advances and challenges. ... considerable advances in the production a nd usage of therapeutic ... polymers as drug carriers for delivery of therapeutic protein s.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295289/
Areas Covered. In this topical review, we highlight recent advances to in vivo delivery of the CRISPR/Cas9 system using various packaging formats, including viral, mRNA, plasmid, and protein-based approaches. We also discuss some of the barriers which have yet to be overcome for successful translation of this technology.Author: D.C. Luther, Y.W. Lee, H. Nagaraj, F. Scaletti, V.M. Rotello
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(19)30053-X
This review addresses the challenges for clinical translation of mRNA-based therapeutics, with an emphasis on recent advances in biomaterials and delivery strategies, and the authors present an overview of the applications of mRNA-based delivery for protein therapy, gene editing, and vaccination.Author: Piotr S. Kowalski, Arnab Rudra, Arnab Rudra, Lei Miao, Daniel G. Anderson
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