We have collected information about Antibody Targeted Sirna Delivery for you. Follow the links to find out details on Antibody Targeted Sirna Delivery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464882/
Targeted siRNA Delivery and mRNA Knockdown Mediated by Bispecific Digoxigenin-binding Antibodies. ... To demonstrate the specificity of targeted siRNA delivery, ... This and the observation of specific antibody-targeted mRNA knockdown make it unlikely that an unspecific response (interferon response) is a major driver of the (target-specific ...Author: Britta Schneider, Michael Grote, Matthias John, Alexander Haas, Birgit Bramlage, Ludger M lckenstein...
https://www.researchgate.net/publication/51485197_Antibody_Targeted_siRNA_Delivery
Antibody Targeted siRNA Delivery. Article ... Our strategy involves the use of antibody-based delivery agents to target and deliver siRNA into specific cell types. We have developed antibody-based ...
https://www.cell.com/molecular-therapy-family/nucleic-acids/pdf/S2162-2531(16)30103-2.pdf
Antibody-mediated siRNA Delivery Schneider et al 2 addition of nonspecific endosome-modulating agents such as chloroquine.7 The objective of the present work was to evaluate the use-fulness of bsAbs in combination with dynamic polyconjugates (DPCs) or lipid-based nanoparticles (LNPs) for targeted delivery of siRNA.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1559924/
Jun 25, 2006 · To overcome these barriers several strategies have been developed, such as chemical modifications of siRNA, viral nucleic acid delivery systems, and nonviral nucleic acid delivery systems. Here, we discuss progress that has been made to improve targeted delivery of …Author: Sabrina Oliveira, Gert Storm, Raymond M. Schiffelers
https://link.springer.com/protocol/10.1007/978-1-61779-188-8_8
Jun 30, 2011 · The labile structure of the linking agents enables release of siRNA molecules post internalization. Using this targeting strategy, we have developed a method that allows any commercially available or recombinant antibody to be conjugated to siRNA for delivery purposes.Author: Masoud M. Toloue, Lance P. Ford
https://www.sciencedirect.com/science/article/pii/S2162253116301032
Targeted siRNA Delivery and mRNA Knockdown Mediated by Bispecific Digoxigenin-binding Antibodies. ... specificity of antibody-mediated siRNA delivery (in sufficient amounts with limited nonspecific delivery), and (iii) optional separation of siRNA or siRNA-containing vehicles from antibodies upon internalization to facilitate efficient transfer ...Author: Britta Schneider, Michael Grote, Matthias John, Alexander Haas, Birgit Bramlage, Ludger M lckenstein...
https://www.hindawi.com/journals/jdd/2017/6971297/
Over the past 20 years, a diverse group of ligands targeting surface biomarkers or receptors has been identified with several investigated to target siRNA to tumors. Many approaches to developing tumor-homing peptides, RNA and DNA aptamers, and single-chain variable fragment antibodies by using phage display, in vitro evolution, and recombinant antibody methods could not have been imagined by ...Author: Qixin Leng, Martin C. Woodle, A. James Mixson
https://academic.oup.com/nar/article/43/2/1189/2414709
Dec 30, 2014 · Abstract. Delivery of siRNA is a key hurdle to realizing the therapeutic promise of RNAi. By targeting internalizing cell surface antigens, antibody–siRNA complexes provide a possible solution.Author: Trinna L. Cuellar, Dwight Barnes, Christopher Nelson, Joshua Tanguay, Shang-Fan Yu, Xiaohui Wen, Suz...
https://www.nature.com/articles/d42859-019-00086-0
Nov 14, 2019 · The major achievement of this work was the proof‑of‑principle demonstration of targeted siRNA delivery in vivo. A similar approach, published a year later, used RNA-based aptamers instead of ...Author: Christian Schnell
https://www.sciencedirect.com/science/article/pii/S1818087614000646
Delivery systems for siRNA drug development in cancer therapy. Author links open overlay panel Cong ... Davis et al. reported the first targeted siRNA delivery nanoparticle in humans via ... The intravenous administration of the antibody-siRNA conjugate led to the efficient suppression of reporter gene expression in a rat model ...Author: Cong-fei Xu, Jun Wang
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