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https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(05)00243-1
A theoretical benefit of a tissue-type and cell-type specific delivery is the prevention of silencing in cells that are not involved in the particular disease. This should expand the number of targets that are suitable for an siRNA therapeutic approach to genes that are essential in non-target cells.Author: Hans-Peter Vornlocher
https://www.researchgate.net/publication/7478760_Antibody-directed_cell-type-specific_delivery_of_siRNA
Antibody-directed cell-type-specific delivery of siRNA Article in Trends in Molecular Medicine 12(1):1-3 · February 2006 with 68 Reads How we measure 'reads'
https://www.ncbi.nlm.nih.gov/pubmed/16290229
Antibody-directed cell-type-specific delivery of siRNA. ... When a mixture of siRNA targeting tumor-related genes was administered in this way, tumor growth was inhibited in an engineered melanoma model, demonstrating the therapeutic potential of this technology. However, several challenges remain to be overcome before targeted gene silencing ...Author: Hans-Peter Vornlocher
https://www.sciencedirect.com/science/article/abs/pii/S1471491405002431
Over the past four years, chemically synthesized short interfering RNA (siRNA) has become the standard tool for specific silencing of gene expression in vitro.The most difficult task in transferring this technology to an in vivo setting is to develop appropriate delivery strategies. With this aim, Song et al. recently reported the development of antibody–protamine fusion proteins as vehicles ...Author: Hans-Peter Vornlocher
https://www.researchgate.net/publication/6168098_Exploring_cell_type-specific_internalizing_antibodies_for_targeted_delivery_of_siRNA
Exploring cell type-specific internalizing antibodies for targeted delivery of siRNA Article · Literature Review in Briefings in Functional Genomics and Proteomics 6(2):112-9 · July 2007 with 17 ...
https://www.ncbi.nlm.nih.gov/pubmed/17670766
Exploring cell type-specific internalizing antibodies for targeted delivery of siRNA. ... The antibody-directed siRNA complex enters target cells through receptor endocytosis and is subsequently released to the cytosol to specifically silence target gene expression through biologically conserved RNA interference (RNAi) pathways. ...Author: Bin Liu
https://academic.oup.com/bfg/article/6/2/112/240665
Jul 31, 2007 · Abstract. A major challenge to the development of therapeutic small interfering RNAs (siRNAs) is specific and efficient in vivo delivery to target cells. Recent studies suggest that cell type-specific gene silencing in vivo can be achieved by combining siRNAs with cell type-specific affinity ligands such as monoclonal antibodies. The antibody-directed siRNA complex enters target cells through ...Author: Bin Liu
https://link.springer.com/article/10.1007/s10059-010-0056-5
Apr 12, 2010 · Targeted mRNA degradation by short interfering RNAs (siRNAs) offers a great potential to treat cancers. siRNA therapeutics for leukemias are, however, hindered by poor intracellular uptake, limited blood stability and nonspecific delivery. To solve these problems, we developed an anti-JL1 immunonanoplex (antibody-coupled nanocomplex) for siRNA delivery using anti-JL1 minibody …Author: Yeon Kyung Lee, Keun Sik Kim, Jung Seok Kim, Jin Ee Baek, Sang Il Park, Hwa Yeon Jeong, Sang Soon Yo...
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