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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955097/
Sep 18, 2013 · The selective silencing of gene expression by small interference RNA (siRNA) is a promising approach for the treatment of a variety of human diseases, including cancer, metabolic, neurodegenerative and infectious disease. 1 However, a major obstacle to the clinical application of RNA interference (RNAi) therapy is the lack of efficient methods for the delivery of siRNAs to the target …Author: Hua Lu, Danling Wang, Stephanie Kazane, Tsotne Javahishvili, Feng Tian, Frank Song, Aaron Sellers, B...
https://link.springer.com/protocol/10.1007/978-1-61779-188-8_8
Jun 30, 2011 · siRNA miRNA delivery antibody directed delivery conjugation kit therapeutic monoclonal antibodies receptor-mediated endocytosis in vivo models therapeutic small RNA. This is a preview of subscription content, log in to check access.Author: Masoud M. Toloue, Lance P. Ford
https://academic.oup.com/nar/article/43/2/1189/2414709
Dec 30, 2014 · The first reports of antibody-mediated siRNA delivery focused narrowly on individual antibody–antigen interactions and only one or a few cell types. We aimed to study ARC-mediated delivery more broadly and to survey how a variety of properties …Author: Trinna L. Cuellar, Dwight Barnes, Christopher Nelson, Joshua Tanguay, Shang-Fan Yu, Xiaohui Wen, Suz...
https://pubs.acs.org/doi/10.1021/ja4059525
We describe here the development of site-specific antibody–polymer conjugates (APCs) for the selective delivery of small interference RNAs (siRNAs) to target cells. APCs were synthesized in good yields by conjugating an aminooxy-derivatized cationic block copolymer to an anti-HER2 Fab or full-length IgG by means of genetically encoded p-acetyl phenylalanine (pAcF). The APCs all showed ...Author: Hua Lu, Danling Wang, Stephanie Kazane, Tsotne Javahishvili, Feng Tian, Frank Song, Aaron Sellers, B...
https://www.cell.com/molecular-therapy-family/nucleic-acids/pdf/S2162-2531(16)30103-2.pdf
Antibody-mediated siRNA Delivery Schneider et al 2 addition of nonspecific endosome-modulating agents such as chloroquine.7 The objective of the present work was to evaluate the use-fulness of bsAbs in combination with dynamic polyconjugates (DPCs) or lipid-based nanoparticles (LNPs) for targeted delivery of siRNA.
https://www.researchgate.net/publication/51485197_Antibody_Targeted_siRNA_Delivery
Antibody Targeted siRNA Delivery. It is very clear that RNA interference (RNAi) is a potent and versatile tool for gene silencing. One of the hurdles to making siRNA/miRNA a human therapeutic includes effective in vivo delivery and being able to deliver drugs to target cells only.
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