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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089357/
4.2 Enhancing antibody delivery through blood-brain barrier disruption (BBBD) The transient disruption of the physical barrier presented by BBB and/or BBTB is another approach to improving CNS delivery of agents that would typically be impermeable.Author: Ann-Marie Chacko, Chunsheng Li, Daniel A. Pryma, Steven Brem, George Coukos, Vladimir R. Muzykantov
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507173/
Jul 20, 2015 · The overall aim of our study was to develop ligand-functionalised polymersomes to facilitate CNS delivery, and more importantly to demonstrate efficient intracellular delivery of a model antibody into CNS resident cells.Author: Xiaohe Tian, Sophie Nyberg, Paul S. Sharp, Jeppe Madsen, Nooshin Daneshpour, Steven P. Armes, Jason ...
https://www.sciencedirect.com/science/article/pii/S0028390816300867
Antibody therapies in CNS diseases. Author links open overlay ... a short 29 amino acid brain-targeting peptide has been derived from the rabies virus glycoprotein (RVG) as a CNS delivery tool. RVG has been suggested to bind to the ... et al.Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta ...Author: Per-Ola Freskgård, Eduard Urich
https://www.nature.com/articles/s41551-019-0434-z
Approximately 15–40% of all cancers develop metastases in the central nervous system (CNS), yet few therapeutic options exist to treat them. Cancer therapies based on monoclonal antibodies are ...Author: Jing Wen, Di Wu, Meng Qin, Chaoyong Liu, Lan Wang, Duo Xu, Harry V. Vinters, Yang Liu, Emiko Kranz, ...
https://www.sciencedirect.com/science/article/pii/S0168365918304590
Delivery of antibody-based therapeutics to the CNS is challenging due to the BBB. • Intranasal delivery can achieve therapeutically relevant levels of IgG in the CNS. • Intranasally applied IgG reaches the CNS via perineural and perivascular pathways. • Intranasal IgG delivery to the CNS has a …Author: Niyanta N. Kumar, Jeffrey J. Lochhead, Michelle E. Pizzo, Geetika Nehra, Sam Boroumand, Gretchen Gre...
https://www.nature.com/articles/srep11990
Jul 20, 2015 · The overall aim of our study was to develop ligand-functionalised polymersomes to facilitate CNS delivery and more importantly to demonstrate efficient …Author: Xiaohe Tian, Sophie Nyberg, Paul S. Sharp, Jeppe Madsen, Nooshin Daneshpour, Steven P. Armes, Jason ...
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