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https://link.springer.com/article/10.1007/s12272-011-1012-4
Nov 12, 2011 · Targeting therapeutics to specific sites can enhance the efficacy of drugs, reduce required doses as well as unwanted side effects. In this work, using the advantages of the specific affinity of an immobilized antibody to membrane P-gp in two different nanoparticle formulations were thus developed for targeted drug delivery to multi-drug resistant cervical carcinoma (KB-V1) cells. Further ...Author: Pantiwa Iangcharoen, Wanisa Punfa, Supachai Yodkeeree, Watchara Kasinrerk, Chadarat Ampasavate, Song...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010380/
P-gp is minimally expressed on normal tissue, but significantly upregulated on MDR cancer cells 37. Targeted drug delivery to MDR cancer cells is considered a strategy for the increased drug sensitivity of the cancer cells via enhancement of drug accumulation and cellular uptake.Author: Wanisa Punfa, Supachai Yodkeeree, Pornsiri Pitchakarn, Chadarat Ampasavate, Pornngarm Limtrakul
https://www.researchgate.net/publication/268874921_Curcumin-loaded_PLGA_Nanoparticles_Conjugated_with_Anti-P-glycoprotein_Antibody_to_Overcome_Multidrug_Resistance
Curcumin-loaded PLGA Nanoparticles Conjugated with Anti-P-glycoprotein Antibody to Overcome Multidrug Resistance ... an active-targeting drug delivery system. ... anti-P-glycoprotein in drug ...
https://www.researchgate.net/publication/318289942_Possible_role_of_nanocarriers_in_drug_delivery_against_cervical_cancer
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https://www.sciencedirect.com/science/article/pii/S2213713014000030
The first strategy may be reached by inhibiting efflux of drug molecules, which have entered cancer cells by passive diffusion. The efflux function of P-glycoprotein can be blocked either by chemical small molecules or therapeutic monoclonal antibodies ().Another approach in this context is an increase of drug uptake into cancer cell by means of nanoparticles.Author: Mohamed Saeed, Maen Zeino, Onat Kadioglu, Manfred Volm, Thomas Efferth
https://www.sciencedirect.com/science/article/pii/S0076687998920201
P-Glycoprotein, a member of the ABC transporter group, plays an important role in anticancer drug resistance. Many monoclonal antibodies to P-glycoprotein have been developed and used to study the molecular and cellular functions of P-glycoprotein.Author: Mikihiko Naito, Takashi Tsuruo
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