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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215191/
Amyloids as a novel depot formulation in drug delivery. The protein/peptide drugs often require special means of delivery such as infusion and subcutaneous administration to prevent them from protease degradation (74, 75). Various formulations of peptide/protein drugs have been developed, which aid in achieving controlled release of drugs over ...Author: Shruti Mankar, A. Anoop, Shamik Sen, Samir Kumar Maji
https://arxiv.org/pdf/1704.08313
Drugs and drug delivery systems targeting amyloid-β in Alzheimer’s disease Morgan Robinson 1, Brenda Yasie Lee 1 and Zoya Leonenko 1, 2, 3, * 1 Department of Biology, University of Waterloo, Waterloo, Ontario, Canada 2 Department of Physics & Astronomy, University of …Author: Morgan Robinson, Brenda Yasie Lee, Zoya Leonenko
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389492/
May 15, 2012 · The successful treatment of Alzheimer’s disease (AD) will require drugs that can negotiate the blood-brain barrier (BBB). However, the BBB is not simply a physical barrier, but a complex interface that is in intimate communication with the rest of the central nervous system (CNS) and influenced by peripheral tissues.Author: William A. Banks
https://www.nytimes.com/2020/02/10/health/alzheimers-amyloid-drug.html
Feb 10, 2020 · Few experts want to give up on the hypothesis that amyloid plaques in the brain are intimately involved in Alzheimer’s disease. ... two drug companies that supplied the …
https://www.nature.com/articles/nrd.2016.14
Jan 29, 2016 · New targets for drug delivery across the BBB. ... BACE1 is the primary generator of amyloid-β, a protein that is hypothesized to have a causal …Author: Katie Kingwell
https://www.nature.com/articles/s41467-019-11593-z
Aug 08, 2019 · During the past several decades, targeted drug delivery systems (TDDS) have gained increasing attention to achieve better therapeutic efficacy …Author: Zui Zhang, Juan Guan, Zhuxuan Jiang, Yang Yang, Jican Liu, Wei Hua, Ying Mao, Cheng Li, Weiyue Lu, J...
https://www.sciencedirect.com/science/article/pii/S0927776513005468
Dec 01, 2013 · Nanoparticles (NPs) or nanoscale objects (<600 Da.), are able to cross the BBB at low concentrations, and can specifically target amyloidogenic structures. Thus, NPs are fast becoming indispensable tools for directed drug delivery, particularly when targeting structures or …Author: Shuchen Hsieh, Chiung-wen Chang, Hsuan-hung Chou
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(19)30253-1/fulltext
Therefore, we demonstrate an Aβ-targeted drug-delivery system, based on the capacity of specific CD4 T cells to effectively migrate within the brain parenchyma, target …Author: Ekaterina Eremenko, Kritika Mittal, Omer Berner, Nikita Kamenetsky, Anna Nemirovsky, Yehezqel Elyahu...
https://www.fda.gov/news-events/press-announcements/fda-approves-first-its-kind-targeted-rna-based-therapy-treat-rare-disease
FDA approves new drug for treatment of polyneuropathy caused by hereditary transthyretin-mediated amyloidosis (hATTR). This is the first FDA-approved treatment for this rare, debilitating and ...
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