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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737653/
Mar 01, 2013 · Alginate has also been applied for oral insulin delivery. 56,64 Insulin encapsulated into alginate nanoparticles reduced the basal serum glucose levels by 40% after oral administration to diabetic rats. 56 In another study, insulin complexed with cationic β-cyclodextrin polymers in alginate/chitosan nanoparticles showed the ability of cationic β-cyclodextrin polymers to protect insulin …Author: Pedro Fonte, Francisca Araújo, Salette Reis, Bruno Sarmento
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619439/
Oct 24, 2015 · Keywords: Nanocarrier, Insulin delivery, Type-1 diabetes mellitus (T1DM), Oral drug delivery, Pulmonary drug delivery Background Diabetes mellitus (hyperglycemia), a metabolic disorder, is caused either due to lower insulin secretion by the cells or due to lower binding efficiency of insulin on their cell surface receptors resulting in high blood glucose level.Author: Garima Sharma, Garima Sharma, Ashish Ranjan Sharma, Ju-Suk Nam, George Priya C. Doss, Sang-Soo Lee, ...
https://www.ncbi.nlm.nih.gov/pubmed/29501738
May 05, 2018 · Oral insulin delivery, the challenge to increase insulin bioavailability: Influence of surface charge in nanoparticle system. Czuba E(1), Diop M(1), Mura C(1), Schaschkow A(1), Langlois A(1), Bietiger W(1), Neidl R(1), Virciglio A(1), Auberval N(2), Julien-David D(3), Maillard E(1), Frere Y(2), Marchioni E(3), Pinget M(1), Sigrist S(4).Author: Elodie Czuba, Mouhamadou Diop, Carole Mura, Anais Schaschkow, Allan Langlois, William Bietiger, Roma...
https://www.sciencedirect.com/science/article/pii/S0168365917308283
Compared to traditional delivery of insulin injection, delivering insulin-loaded nanoparticle through the oral route is preferable because it can improve patient compliance and reduce local discomfort.Author: Chun Y. Wong, Hani Al-Salami, Crispin R. Dass
https://www.onlinelibrary.wiley.com/doi/full/10.1111/jphp.12852
Nov 28, 2017 · Based on nature, polymers utilized in fabrication of insulin nanoparticles are either of natural or synthetic origin. 111, 112 Gelatin and casein, examples of natural protein polymers, have been used to prepare insulin‐loaded nanoparticles for per‐oral delivery with promising results and good safety profile. 112 Natural polysaccharide ...Author: Ahmed Gedawy, Jorge Martinez, Hani Al‐Salami, Crispin R. Dass
https://www.nature.com/articles/s41551-019-0465-5
In healthy mice, silica nanoparticles enabled the oral delivery of insulin and exenatide, with 10 U kg −1 orally delivered insulin sustaining hypoglycaemia for a few hours longer than a 1 U kg −1...Author: Nicholas G. Lamson, Adrian Berger, Katherine C. Fein, Kathryn A. Whitehead
https://www.sciencedirect.com/science/article/pii/S073497501500035X
PLGA, an aliphatic polyester co-polymer, is one of the most used synthetic polymer to produce nanoparticles for the oral delivery of insulin, mainly due to its biodegradability and biocompatibility properties as well as sustained release profiles.Author: Pedro Fonte, Francisca Araújo, Cátia Silva, Carla Pereira, Salette Reis, Hélder A. Santos, Bruno Sar...
https://www.ncbi.nlm.nih.gov/pubmed/28887133
Oct 28, 2017 · Nanoparticles have demonstrated significant advancements in potential oral delivery of insulin. In this publication, we review the current status of polymeric, inorganic and solid-lipid nanoparticles designed for oral administration of insulin. Firstly, the structure and physiological function of insulin are examined.Author: Chun Y. Wong, Hani Al-Salami, Crispin R. Dass
https://www.sciencedirect.com/science/article/pii/S0169409X12003535
Oral delivery of protein has become a pressing goal in recent years due to the increased availability of novel therapeutics through the advent of recombinant DNA technology. One of the holy grails of oral drug delivery is to deliver proteins, such as insulin, with …Author: Yeonhee Yun, Yeonhee Yun, Yong Woo Cho, Kinam Park, Kinam Park
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