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https://www.ncbi.nlm.nih.gov/pubmed/15248808
Carrier properties, mechanisms of drug release, and study of release kinetics help to improve the predictability of performance. The review also addresses the various barriers in the design of amorphous delivery systems, use of amorphous form in controlled release delivery systems, and their in vivo performance. PMID: 15248808 [Indexed for MEDLINE]Author: Aditya Mohan Kaushal, Piyush Gupta, Arvind Kumar Bansal
https://www.researchgate.net/profile/Arvind_Bansal/publication/8460156_Amorphous_Drug_Delivery_Systems_Molecular_Aspects_Design_and_Performance/links/53ea1ab00cf2fb1b9b6761bb.pdf
amorphous drug delivery systems to ionic drugs, which excludes the use of this strategy for neutral drug molecules.²⁹ From the regulatory perspective, the approval of prodrugs and salts is a ...
https://www.sciencedirect.com/science/article/pii/S0169409X1530003X
Co-amorphous drug delivery systems have recently gained considerable interest in the pharmaceutical field because of their potential to improve oral bioavailability of poorly water-soluble drugs through drug dissolution enhancement as a result of the amorphous nature of the material.Author: Swapnil Jayant Dengale, Holger Grohganz, Thomas Rades, Korbinian Löbmann
https://www.sciencedirect.com/science/article/pii/S0378517317308426
Amorphous solid dispersions (ASDs) are probably the most common and important supersaturating drug delivery systems for the formulation of poorly water-soluble compounds. These delivery systems are able to achieve and maintain a sustained drug supersaturation which enables improvement of the bioavailability of poorly water-soluble drugs by ...Author: Riikka Laitinen, Korbinian Löbmann, Holger Grohganz, Petra Priemel, Clare J. Strachan, Thomas Rades,...
http://dl.begellhouse.com/journals/3667c4ae6e8fd136,16e2a9f911dc5f33,4c11e55e55217865.html
Carrier properties, mechanisms of drug release, and study of release kinetics help to improve the predictability of performance. The review also addresses the various barriers in the design of amorphous delivery systems, use of amorphous form in controlled release delivery systems, and their in …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964012/
Jan 15, 2020 · The application of nanosuspensions in oral, ocular and pulmonary drug delivery systems have been extensively researched during the last few decades. Further, utilization of nanosuspensions in other drug delivery systems such as brain, topical, buccal, nasal and transdermal routes are under extensive investigation.Author: Shery Jacob, Anroop B. Nair, Jigar Shah
http://www.pssrc.org/news/82
Drug-Drug combinations. Co-amorphous drug-drug formulations were introduced by Chieng et al. (2009) as new delivery systems for poorly water-soluble drugs that are suitable for combination therapy, i.e. with similar doses and pharmacological profile. The feasibility of this approach has been shown for several drug-drug combinations [5]. These ...
https://www.researchgate.net/publication/327053307_Advances_in_Coamorphous_Drug_Delivery_Systems
coamorphous drug delivery systems from the perspectives of preparation, physicochemical characteristics, ... followed by CLZ-oxalic acid and CLZ-citric acid amorphous systems. 104.
https://www.pharmaexcipients.com/news/vitamin-e-tpgs-vs-amorphous-solid-dispersion-as-oral-delivery-systems-for-etoposide/
The purpose of thisresearch was to investigate the solubility-permeability interplay when using TPGS vs. amorphous solid dispersions (ASD) as oral drug delivery systems for the anticancer, P-gp substrate, lipophilicdrug etoposide.
https://pubs.acs.org/doi/abs/10.1021/mp2002973
One of the challenges in drug development today is that many new drug candidates are poorly water-soluble, and one of the approaches to overcome this problem is to transfer a crystalline drug into its amorphous form, thus increasing dissolution rate and apparent solubility of the compound. In this study, a coamorphous drug/drug combination between the two nonsteroidal anti-inflammatory drugs ...Author: Korbinian Löbmann, Riikka Laitinen, Holger Grohganz, Keith C. Gordon, Clare Strachan, Thomas Rades
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