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https://www.ncbi.nlm.nih.gov/pubmed/15248808
Carrier properties, mechanisms of drug release, and study of release kinetics help to improve the predictability of performance. The review also addresses the various barriers in the design of amorphous delivery systems, use of amorphous form in controlled release delivery systems, and their in vivo performance. PMID: 15248808 [Indexed for MEDLINE]Author: Aditya Mohan Kaushal, Piyush Gupta, Arvind Kumar Bansal
https://onlinelibrary.wiley.com/doi/10.1002/anie.201907652
Sep 24, 2019 · Enhanced Drug Delivery by Dissolution of Amorphous Drug Encapsulated in a Water Unstable Metal–Organic Framework (MOF) Dr. Kuthuru Suresh. Department of Chemistry and the Macromolecular Science and Engineering Program, University of Michigan, 930 North University Avenue, Ann Arbor, MI, 48109-1055 USA.Author: Kuthuru Suresh, Adam J. Matzger
https://www.sciencedirect.com/science/article/pii/S0169409X1530003X
Co-amorphous drug delivery systems have recently gained considerable interest in the pharmaceutical field because of their potential to improve oral bioavailability of poorly water-soluble drugs through drug dissolution enhancement as a result of the amorphous nature of the material.Author: Swapnil Jayant Dengale, Holger Grohganz, Thomas Rades, Korbinian Löbmann
https://www.sciencedirect.com/science/article/pii/S0169409X16300047
In this review, amorphous powders for inhalation drug delivery are discussed focusing on the methods for powder production, amorphous inhalable drugs and functional excipients for DPI formulations. Suitable devices for amorphous DPI formulations and the approaches for promoting the stability of amorphous powders are also highlighted. 2.Author: Lan Chen, Tomoyuki Okuda, Tomoyuki Okuda, Xiang-Yun Lu, Hak-Kim Chan
https://www.ondrugdelivery.com/the-science-of-solubility-and-the-success-of-amorphous-solid-dispersions/
Rashmi Nair discusses the persistent challenge presented by poorly soluble drug formulations in oral drug delivery. Furthermore, she goes on to highlight the promise shown by amorphous solid dispersions, despite the difficulties they present.
https://www.ncbi.nlm.nih.gov/pubmed/11325475
May 16, 2001 · 1. Adv Drug Deliv Rev. 2001 May 16;48(1):27-42. Amorphous pharmaceutical solids: preparation, characterization and stabilization. Yu L(1). Author information: (1)Eli Lilly and Company, Lilly Research Laboratories, Lilly Corporate Center, DC3811, Indianapolis, IN 46285, USA. [email protected] The importance of amorphous pharmaceutical solids lies in their useful properties, common …Author: Lian Yu
https://www.researchgate.net/profile/Arvind_Bansal/publication/8460156_Amorphous_Drug_Delivery_Systems_Molecular_Aspects_Design_and_Performance/links/53ea1ab00cf2fb1b9b6761bb.pdf
amorphous drug delivery systems to ionic drugs, which excludes the use of this strategy for neutral drug molecules.²⁹ From the regulatory perspective, the approval of prodrugs and salts is a ...
https://www.researchgate.net/publication/290175345_Amorphous_powders_for_inhalation_drug_delivery
For inhalation drug delivery systems such as dry powder inhalation, amorphous powders obtained by spray drying process may have poor physical stability affecting their aerosol performance (Chen et ...
https://drug-dev.com/formulation-forum-amorphous-formulations-for-insoluble-drugs-rational-design-practical-approaches-on-formulation-screening-development/
AMORPHOUS DRUG DELIVERY SYSTEMS. Amorphous API If the amorphous API can be reproducibly manufactured, and it possesses characteristics that could maintain its physical-chemical properties during process, storage, and in vivo physiological conditions, eg, a high transition point, (Tg-Tstorage > 50°C), strong glass former, non-hygroscopicity, and ability to maintain supersaturation in GI fluid ...
http://dl.begellhouse.com/journals/3667c4ae6e8fd136,16e2a9f911dc5f33,4c11e55e55217865.html
Carrier properties, mechanisms of drug release, and study of release kinetics help to improve the predictability of performance. The review also addresses the various barriers in the design of amorphous delivery systems, use of amorphous form in controlled release delivery systems, and their in …
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