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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769556/
Feb 27, 2016 · Albumin binds to endogenous ligands such as fatty acids; however, it also interacts with exogenous ligands such as warfarin, penicillin and diazepam. As the binding of these drugs to albumin is reversible the albumin-drug complex serves as a drug reservoir that can enhance the drug biodistribution and bioavailability.Author: Maja Thim Larsen, Matthias Kuhlmann, Michael Lykke Hvam, Kenneth A. Howard
https://molcelltherapies.biomedcentral.com/articles/10.1186/s40591-016-0048-8
Feb 27, 2016 · The effectiveness of a drug is dependent on accumulation at the site of action at therapeutic levels, however, challenges such as rapid renal clearance, degradation or non-specific accumulation requires drug delivery enabling technologies. Albumin is a natural transport protein with multiple ligand binding sites, cellular receptor engagement, and a long circulatory half-life due to …Author: Maja Thim Larsen, Matthias Kuhlmann, Michael Lykke Hvam, Kenneth A. Howard
https://www.sciencedirect.com/science/article/pii/S0168365911008546
Abraxane ®, an albumin-paclitaxel nanoparticle, is the most advanced drug product of the so-called nab technology developed by American Bioscience in which a lipophilic drug and human serum albumin are passed through a jet under high pressure to form nab -paclitaxel nanoparticles with a …Author: Bakheet Elsadek, Felix Kratz
https://www.ncbi.nlm.nih.gov/pubmed/31916145
Jan 08, 2020 · Albumin is a biocompatible, non-immunogenic and versatile drug carrier system. It has been widely used to extend the half-life, enhance stability, provide protection from degradation and allow specific targeting of therapeutic agents to various disease states.Author: Shrawani Lamichhane, Sangkil Lee
https://www.tandfonline.com/doi/abs/10.1080/17425247.2016.1193149
Jun 09, 2015 · Albumin has a range of natural molecular binding sites that can be used for drug delivery. Albumin nanostructures can solubilize insoluble drugs, reduce toxicity to surrounding normal cells, and protect nucleic acids from degradation.Author: Mahdi Karimi, Sajad Bahrami, Soodeh Baghaee Ravari, Parham Sahandi Zangabad, Hamed Mirshekari, Mahna...
https://pdfs.semanticscholar.org/1841/a789b5dbfdbc2b3523cd3ddb4d1e2949821d.pdf
Albumin comprises about half of the blood serum protein. Human serum albumin (molecular weight of 65 kDa) belongs to a multigene family of proteins (He and Carte 1992) and is the major soluble protein of the circulating system with a blood concentration about 50 mg.ml-1.
https://www.researchgate.net/publication/288887920_Human_Serum_Albumin_as_Carrier_in_Drug_Delivery_Systems
Recently, human serum albumin (HSA) has emerged as a versatile carrier for therapeutic agents against diabetes, cancer, and infectious diseases. Market-approved products include fatty acid derivatives of human insulin for diabetes and the paclitaxel-HSA nanoparticle for various cancers such as metastatic breast cancer and advanced pancreatic cancer.
https://www.uspharmacist.com/article/drug-delivery-systems-for-cancer-therapeutics
Sep 20, 2011 · Two types of drug delivery systems—liposomal and albumin nanoparticle drugs—have caused notable improvement in the therapeutic index of anticancer agents; however, the lack of success in improving overall survival makes it imperative to further develop and refine drug delivery systems.
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