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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769556/
Feb 27, 2016 · Albumin-based drug delivery strategies. The natural transport function, multiple ligand binding sites, and cellular interactions provides rational for the exploitation of albumin for drug delivery. The ability to covalent and non-covalently attach drugs or expression of albumin-drug fusions provides a range of design options ...Author: Maja Thim Larsen, Matthias Kuhlmann, Michael Lykke Hvam, Kenneth A. Howard
https://molcelltherapies.biomedcentral.com/articles/10.1186/s40591-016-0048-8
Feb 27, 2016 · The effectiveness of a drug is dependent on accumulation at the site of action at therapeutic levels, however, challenges such as rapid renal clearance, degradation or non-specific accumulation requires drug delivery enabling technologies. Albumin is a natural transport protein with multiple ligand binding sites, cellular receptor engagement, and a long circulatory half-life due to …Author: Maja Thim Larsen, Matthias Kuhlmann, Michael Lykke Hvam, Kenneth A. Howard
https://www.tandfonline.com/doi/full/10.1517/17425247.2015.993313
Jun 03, 2016 · 2. Albumin in drug delivery. Human albumin is a single non-glycosylated polypeptide chain of 585 amino acids with a molecular weight of 66,439 Da. Synthesised predominantly in the liver, albumin performs a number of important functions including the maintenance of oncotic pressure, transport and distribution of a variety of endogenous and exogenous ligands and contributing to the …Author: Darrell Sleep
https://www.tandfonline.com/doi/abs/10.1517/17425247.2015.993313
Jun 03, 2016 · Albumin naturally accumulates at tumours and sites of inflammation, a characteristic which can be augmented by the addition of targeting ligands. The development of albumin drug conjugates which reply upon this property is described. Expert opinion: Albumin’s inherent biochemical and biophysical properties make it an ideal drug delivery ...Author: Darrell Sleep
https://www.sciencedirect.com/science/article/pii/S0168365911008546
Skimming the publications on albumin-based drug delivery systems that had appeared since 2008, we were intrigued about the increasing number of approved products based on albumin, ongoing clinical trials and novel applications and insights in the preclinical setting.Author: Bakheet Elsadek, Felix Kratz
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