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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232389/
Aerosol delivery of Akt1 WT and naphthalene treatment increased protein levels of downstream substrates of Akt signaling pathway while aerosol delivery of Akt1 KD did not. Our results showed that naphthalene affected extracellular signal-regulated kinase (ERK) protein levels, ERK-related signaling, and induced Clara cell injury.Author: Arash Minai-Tehrani, Young Chan Park, Soon Kyung Hwang, Jung Taek Kwon, Seung Hee Chang, Sung Jin Pa...
https://www.sciencedirect.com/science/article/pii/S0378517316309139
Nov 20, 2016 · Furthermore, its efficient in vivo delivery of shAkt1 to the lung and therapeutic effects in suppression of tumor number and growth by inhibiting Akt signaling pathway evidently validated that aerosol-mediated delivery of FA-HPSPE/shAkt1 complexes could achieve lung cancer-targeted gene therapy. Altogether, FA-modified HPSPE could successfully ...Author: Cheng-Qiong Luo, Yoonjeong Jang, Lei Xing, Peng-Fei Cui, Jian-Bin Qiao, Ah Young Lee, Hyeon-Jeong Ki...
https://www.nature.com/articles/3302879
Oct 19, 2006 · Aerosol delivery of wild-type Akt enhanced cap-dependent protein translation. To determine the changes in protein expression of the Akt signaling pathway in the lungs of …Author: Tehrani Am, Hwang Sk, Kim Th, Cho Cs, Hua J, Nah Ws, Kwon Jt, Kim Js, Chang Sh, Yu Kn, Park Sj, Bhan...
https://cancerres.aacrjournals.org/content/64/21/7971
Nov 01, 2004 · Aerosol PTEN gene delivery caused a substantial reduction in p70S6K and cyclin D1 protein levels and a more modest reduction in 4EBP1(Fig. 3) ⇓ relative to control. These results suggest that aerosol delivery resulted in an increase in PTEN protein levels and that this increase correlated with decreased activation of Akt signaling.Author: Hyun Woo Kim, In Kyu Park, Chong Su Cho, Kee Ho Lee, George R. Beck, Nancy H. Colburn, Myung Haing C...
https://www.atsjournals.org/doi/full/10.1164/rccm.200707-1022OC
Jul 01, 2008 · Tehrani AM, Hwang SK, Kim TH, Cho CS, Hua J, Nah WS, Kwon JT, Kim JS, Chang SH, Yu KN, et al. Aerosol delivery of Akt controls protein translation in the lungs of dual luciferase reporter mice. Gene Ther 2007 ;14: 451 –458.Author: Cheng-Xiong Xu, Dhananjay Jere, Hua Jin, Seung-Hee Chang, Youn-Sun Chung, Ji-Young Shin, Ji-Eun Kim,...
https://www.redorbit.com/news/health/1459846/polyester_aminemediated_aerosoldelivered_akt1_small_interfering_rna_suppresses_lung_tumorigenesis/
Jul 02, 2008 · Tehrani AM, Hwang SK, Kim TH, Cho CS, Hua J, Nah WS, Kwon JT, Kim JS, Chang SH, Yu KN, et al. Aerosol delivery of Akt controls protein translation in the lungs of …
https://www.researchgate.net/publication/51832176_Aerosol_delivery_of_kinase-deficient_Akt1_attenuates_Clara_cell_injury_induced_by_naphthalene_in_the_lungs_of_dual_luciferase_mice
Aerosol delivery of Akt1 WT and naphthalene treatment increased protein levels of downstream substrates of Akt signaling pathway while aerosol delivery of Akt1 KD did not.
https://www.researchgate.net/profile/Ji_Young_Shin/publication/5542880_Polyester_amine-mediated_Aerosol-delivered_Akt1_Small_Interfering_RNA_Suppresses_Lung_Tumorigenesis/links/0046352269911e2a3e000000/Polyester-amine-mediated-Aerosol-delivered-Akt1-Small-Interfering-RNA-Suppresses-Lung-Tumorigenesis.pdf
Small Interfering RNA Suppresses Lung Tumorigenesis ... and aerosol delivery of Akt1 siRNA may be a promising ... Akt (protein kinase B) is an important regulator of cell sur- ...
https://www.sciencedirect.com/science/article/pii/S0378517311008167
Also, aerosol delivery of Akt1 shRNA to the K-ras LA1 lung cancer model mice induced high transfection efficiency with significantly decreased tumor formation [Fig. 6A–D] through Akt signaling pathway [Fig. 6E] without toxicity . Download : Download full-size image; Fig. 5. In vivo analysis after aerosol administration to lungs. Two days ...Author: Hu-Lin Jiang, Seong-Ho Hong, You-Kyoung Kim, Mohammad Ariful Islam, Hye-Joon Kim, Yun-Jaie Choi, Jae...
https://www.atsjournals.org/doi/abs/10.1164/rccm.200707-1022OC
Recent advances in aerosol-mediated gene delivery have provided the possibility of an alternative for the safe and effective treatment of lung cancer. Objectives : To demonstrate the feasibility and emphasize the importance of noninvasive aerosol delivery of Akt1 small interfering RNA (siRNA) as an effective and selective option for lung cancer ...Author: Cheng-Xiong Xu, Dhananjay Jere, Hua Jin, Seung-Hee Chang, Youn-Sun Chung, Ji-Young Shin, Ji-Eun Kim,...
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