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https://www.researchgate.net/publication/6717377_Advances_in_strategies_to_improve_drug_delivery_to_brain_tumors
Advances in the biology of the blood-brain barrier are improving the ability of researchers to target therapeutic peptides, small molecules and other drugs to brain tumors.
https://www.news-medical.net/news/20191202/Strategies-for-improving-drug-delivery-to-treat-brain-tumors.aspx
Costas Arvanitis, of Georgia Institute of Technology, studies the processes affecting therapeutic drug penetration into brain tumors. He will present two strategies for improving the delivery of ...
http://europepmc.org/abstract/MED/17078789
Nov 01, 2006 · Brain tumors remain a significant health problem. Advances in the biology of the blood-brain barrier are improving the ability of researchers to target therapeutic peptides, small molecules and other drugs to brain tumors. Simple methods to improve blood-brain barrier penetration include chemical modification, glycosylation and pegylation. Drug-delivery vehicles, such as nanoparticles …Author: Herbert B Newton
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493051/
Therapeutic strategies to improve drug delivery across the blood-brain barrier. Tej D. Azad ... Resection of brain tumors is followed by chemotherapy and radiation to ablate remaining malignant cell populations. ... as a drug can be administered directly to the brain and with sustained release. Advances in biomaterials will also be able to ...Author: Tej D. Azad, James Pan, Ian D. Connolly, Austin Remington, Christy M. Wilson, Gerald A. Grant
https://www.hindawi.com/journals/jir/2020/8459496/
Combination therapy is another strategy for improving antitumor ability, especially in combination with oncolytic viruses and nanomaterials. In this paper, the mechanisms affecting the activity of NK cells were reviewed, and the therapeutic potential of different basic NK cell strategies in tumor therapy …Author: Chaopin Yang, Yue Li, Yaozhang Yang, Zhiyi Chen
https://academic.oup.com/neuro-oncology/article/18/1/27/2509241
Sep 10, 2015 · We further describe potential strategies to overcome these drug delivery limitations. Understanding the key factors that limit drug delivery into brain tumors will guide future development of approaches for enhanced delivery of effective drugs to GBM.Author: Rajneet K. Oberoi, Karen E. Parrish, Terence T. Sio, Rajendar K. Mittapalli, William F. Elmquist, Ja...
https://www.sciencedirect.com/science/article/pii/S2211383514000288
In this review, we briefly describe physiological and pathological conditions of brain tumors, including blood–brain/brain tumor barriers, tumor microenvironment and tumor stem cells; we review the corresponding targeting delivery strategies and introduce a systematic targeted drug delivery strategy to overcome current challenges.Author: Xiaoli Wei, Xishan Chen, Man Ying, Weiyue Lu
https://link.springer.com/article/10.1007/s11481-016-9698-1
Jul 23, 2016 · In its neuroprotective function, BBB prevents the entry of toxins, as well as most of anticancer agents and is the main impediment for brain targeted drug delivery approaches. Nanotechnology-based delivery systems provide an attractive strategy to cross the BBB and reach the central nervous system (CNS).Author: Jianing Meng, Vivek Agrahari, Ibrahima Youm
http://www.thno.org/v08p1481.pdf
Still, systemic delivery is one area with a great unmet need when using viral vectors for CNS gene therapy. Advances in new vectors and delivery technologies in this area will accelerate the translation and application of viral vectors from preclinical to clinical studies. Table 1. Strategies for brain drug delivery.
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