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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679213/
May 15, 2009 · In conclusion, it is possible to deliver BLM with the aid of a VLP, Ad Dd, in order to significantly improve drug bioavailability. These experiments open new vistas for improved delivery of impermeant labile drugs, bringing us closer to in vivo use of adenovirus dodecahedron as a delivery vector.Author: Monika Zochowska, Agnieszka Paca, Guy Schoehn, Jean-Pierre Andrieu, Jadwiga Chroboczek, Jadwiga Chro...
https://www.ncbi.nlm.nih.gov/pubmed/19440379
Adenovirus dodecahedron, as a drug delivery vector. Zochowska M(1), Paca A, Schoehn G, Andrieu JP, Chroboczek J, Dublet B, Szolajska E. Author information: (1)Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland. BACKGROUND: Bleomycin (BLM) is an anticancer antibiotic used in many cancer regimens.Author: Monika Zochowska, Agnieszka Paca, Guy Schoehn, Jean-Pierre Andrieu, Jadwiga Chroboczek, Jadwiga Chro...
https://www.researchgate.net/publication/24425539_Adenovirus_Dodecahedron_as_a_Drug_Delivery_Vector
We propose to improve BLM delivery by tethering it to an efficient delivery vector. Adenovirus (Ad) dodecahedron base (DB) is a particulate vector composed of 12 copies of a pentameric viral ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005569
The latter can affect up to nearly 50% of the total patient population, out of which 3% will die. We propose to improve BLM delivery by tethering it to an efficient delivery vector. Adenovirus (Ad) dodecahedron base (DB) is a particulate vector composed of 12 copies of a pentameric viral protein responsible for virus penetration.Author: Monika Zochowska, Agnieszka Paca, Guy Schoehn, Jean-Pierre Andrieu, Jadwiga Chroboczek, Jadwiga Chro...
https://www.researchgate.net/profile/Monika_Zochowska/publication/24425539_Adenovirus_Dodecahedron_as_a_Drug_Delivery_Vector/links/0912f505c271464217000000.pdf?origin=publication_detail
Adenovirus Dodecahedron, as a Drug Delivery Vector Monika Zochowska1, Agnieszka Paca1¤, Guy Schoehn2, Jean-Pierre Andrieu3, Jadwiga Chroboczek1,3*, Bernard Dublet3, Ewa …
https://www.hindawi.com/journals/btri/2016/5030589/
Penton-dodecahedron (Pt-Dd) derived from adenovirus type 3 is a symmetric complex of pentameric penton base plus fiber which can be produced in the baculovirus system at a high concentration. The size of Pt-Dd is smaller than the virus, but this virus-like particle (VLP) has the major proteins recognized by specific receptors on the surface of almost all types of cell. In this study, by direct ...Author: Sumarheni, Sumarheni, Benoit Gallet, Pascal Fender
https://www.sciencedirect.com/science/article/pii/S1549963418300923
The covalent attachment of doxorubicin to Dd enables efficient drug delivery and significantly enhances cytotoxicity in multidrug resistant cancer cells in vitro.Importantly, the affinity of Dd in human blood ex vivo is highly in favor of leukocytes, independently of their subtypes despite high representation of red blood cells and platelets. Thus, current results demonstrate that Dd is a ...Author: Marta Jedynak, David Laurin, Patryk Dolega, Malgorzata Podsiadla-Bialoskorska, Inga Szurgot, Jadwiga...
https://link.springer.com/article/10.1007/s12033-015-9850-9
Feb 26, 2015 · Adenoviral dodecahedron (Dd) is a virus-like particle composed of twelve pentameric penton base (Pb) proteins, responsible for adenovirus cell penetration. It is generated spontaneously in the baculovirus system upon expression of the Pb gene of adenovirus serotype 3. This particle shows remarkable cell penetration ability with 2,00,000–3,00,000 Dd internalized into one cell in culture ...Author: Inga Szurgot, M Jedynak, M Podsiadla-Bialoskorska, Jan Piwowarski, Ewa Szolajska, Jadwiga Chroboczek...
https://core.ac.uk/display/104580762
The latter can affect up to nearly 50 % of the total patient population, out of which 3 % will die. We propose to improve BLM delivery by tethering it to an efficient delivery vector. Adenovirus (Ad) dodecahedron base (DB) is a particulate vector composed of 12 copies of a pentameric viral protein responsible for virus penetration.
http://core.ac.uk/display/8285056
Adenovirus Dodecahedron, as a Drug Delivery Vector By Monika Zochowska, Agnieszka Paca, Guy Schoehn, Jean-Pierre Andrieu, Jadwiga Chroboczek, Bernard …
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