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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679008/
Apr 23, 2009 · Acetylation of dendrimers reduced the cellular delivery of siRNA which correlated with a reduction in the buffering capacity of dendrimers upon amine acetylation. Confocal microscopy confirmed that escape from endosomes is a major barrier to siRNA delivery in this system.Author: Carolyn L Waite, Sarah M Sparks, Kathryn E Uhrich, Charles M Roth
https://www.ncbi.nlm.nih.gov/pubmed/19389227
Apr 23, 2009 · Acetylation of dendrimers reduced the cellular delivery of siRNA which correlated with a reduction in the buffering capacity of dendrimers upon amine acetylation. Confocal microscopy confirmed that escape from endosomes is a major barrier to siRNA delivery in this system. CONCLUSION: Primary amine acetylation of PAMAM dendrimers reduced their cytotoxicity to U87 cells, and promoted the release of siRNA from dendrimer/siRNA …Author: Carolyn L Waite, Sarah M Sparks, Kathryn E Uhrich, Charles M Roth
https://bmcbiotechnol.biomedcentral.com/articles/10.1186/1472-6750-9-38
One motivation behind amine acetylation of PAMAM dendrimers was to promote polymer-siRNA unpackaging in cells. That is, self-assembled vectors for siRNA delivery must associate strongly enough to remain intact during cellular binding and entry, yet they must dissociate at some point within cells to release their cargo.Author: Carolyn L Waite, Sarah M Sparks, Kathryn E Uhrich, Charles M Roth
https://www.researchgate.net/publication/24354721_Acetylation_of_PAMAM_dendrimers_for_cellular_delivery_of_siRNA
In this work, the extent of primary amine acetylation of generation 5 poly(amidoamine) (PAMAM) dendrimers was studied as a modification for the delivery of siRNA to U87 malignant glioma cells....
https://core.ac.uk/display/99942729
Acetylation of dendrimers reduced the cellular delivery of siRNA which correlated with a reduction in the buffering capacity of dendrimers upon amine acetylation.
https://pubs.acs.org/doi/10.1021/bc0603889
Oct 26, 2007 · Polyamidoamine (PAMAM) dendrimers are promising candidates for oral drug delivery due to their well-defined compact structure, versatility of surface functionalities, low polydispersity, and ability to enhance transepithelial transport.Author: Rohit B. Kolhatkar, Kelly M. Kitchens, Peter W. Swaan, Hamidreza Ghandehari
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