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https://pubs.acs.org/doi/abs/10.1021/bc049853x
These acetal linkages are therefore promising for use in a variety of drug delivery applications ranging from polymer−drug conjugates to pH-sensitive micelles and nanoparticulate systems. Cited ByAuthor: Elizabeth R. Gillies, and Andrew P. Goodwin, Jean M. J. Fréchet
https://www.researchgate.net/publication/321273539_A_hyperbranched_amphiphilic_acetal_polymer_for_pH-sensitive_drug_delivery
More recently, Wang group designed a new hyperbranched amphiphilic acetal polymers for pH-sensitive drug delivery [63]. Under neutral conditions, the block copolymers self-assembled into well ...
https://experts.umn.edu/en/publications/a-hyperbranched-amphiphilic-acetal-polymer-for-ph-sensitive-drug-
title = "A hyperbranched amphiphilic acetal polymer for pH-sensitive drug delivery", abstract = "Nanoparticles are appealing drug delivery systems since they promise prolonged circulation time and predictable release behaviors.Author: Hongliang Cao, Chao Chen, Debiao Xie, Xin Chen, Ping Wang, Ping Wang, Yibing Wang, Huajie Song, Wenx...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912992/
Polymers with pH-sensitive chemical linkages, such as hydrazone, acetal, ortho ester and vinyl ester, pH-sensitive cell-penetrating peptides and cationic polymers undergoing pH-dependent protonation have been studied to utilize the pH gradient along the endocytic pathway for intracellular drug delivery.Author: Takayuki Yoshida, Tsz Chung Lai, Glen S Kwon, Kazuhiro Sako
https://pubs.acs.org/doi/10.1021/acsabm.0c00086
Acetal-functionalized pillar[5]arene (Ac-PA[5]) was prepared as a pH-responsive biomaterial. This biomaterial could be fabricated into nanoparticles with a narrow size distribution by an emulsion protocol. PA[5]-based nanoparticles were used to deliver anti-tumor drugs (paclitaxel and doxorubicin) in vitro. PA[5]-based nanoparticles were discovered to be a versatile drug delivery system (DDS ...Author: Shang Lan, Yamin Liu, Kejia Shi, Da Ma
https://www.sigmaaldrich.com/technical-documents/articles/material-matters/polymersomes-for-drug-delivery.html
An alternate method of pH-stimulated drug delivery from polymersome vesicles, involves linking the polymer blocks through a pH-sensitive bond, such as an imine, hydrazone, or acetal. 4 Upon exposure to acidic conditions, the link between the hydrophilic and hydrophobic block degrades, leading to the breakdown of the polymersome and release of ...
https://pubs.rsc.org/en/content/articlelanding/2018/py/c7py01739a
Nanoparticles are appealing drug delivery systems since they promise prolonged circulation time and predictable release behaviors. The current work reports a novel hyperbranched amphiphilic block copolymer synthesized using deactivation-enhanced atom transfer radical polymerization (DE-ATRP) for smart drug delivery.Author: Hongliang Cao, Chao Chen, Debiao Xie, Xin Chen, Ping Wang, Ping Wang, Yibing Wang, Huajie Song, Wenx...
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/drug-delivery-vehicle
G BARRATT, in Artificial Cells, Cell Engineering and Therapy, 2007. 3.5 Future trends. Colloidal drug delivery vehicles have been studied in the laboratory for more than 30 years, but the few liposome-based formulations already on the market are mainly concerned with reducing the side effects of the encapsulated drugs. Now that the interactions between particles and biological milieux are ...
https://www.sciencedirect.com/science/article/pii/S0928493117327017
Jan 01, 2018 · Acetal-linked PEGylated paclitaxel prodrugs forming free-paclitaxel-loaded pH-responsive micelles with high drug loading capacity and improved drug delivery Author links open overlay panel Da Huang a b Yaping Zhuang a b Hong Shen a Fei Yang a b Xing Wang a Decheng Wu a bAuthor: Da Huang, Yaping Zhuang, Hong Shen, Fei Yang, Xing Wang, Decheng Wu
https://en.wikipedia.org/wiki/Polyorthoester
Applications. Polyorthoesters are used as hydrophobic implant materials for drug depots for continuous drug delivery by surface erosion. The active ingredient (which is homogeneously dispersed in a matrix of polyorthoester) should be released as evenly as possible into the human or animal organism over an extended period of time in a zero-order release kinetics.
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