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http://www.nature.com/articles/nnano.2009.341
Nov 22, 2009 · We report a novel intracellular delivery platform based on nanocapsules that consist of a single-protein core and thin polymer shell anchored covalently to the protein core.
https://www.researchgate.net/profile/Zheng_Liu14/publication/40028951_A_novel_intracellular_protein_delivery_platform_based_on_single-protein_nanocapsules/links/541a5e330cf2218008bfb232.pdf
A novel intracellular protein delivery platform based on single-protein nanocapsules Ming Yan1†,JuanjuanDu1†,ZhenGu1, Min Liang2, Yufang Hu3, Wenjun Zhang1, Saul …
https://www.ncbi.nlm.nih.gov/pubmed/19935648
A novel intracellular protein delivery platform based on single-protein nanocapsules. Yan M(1), Du J, Gu Z, Liang M, Hu Y, Zhang W, Priceman S, Wu L, Zhou ZH, Liu Z, Segura T, Tang Y, Lu Y. Author information: (1)Department of Chemical and Biomolecular Engineering, University of California at Los Angeles, Los Angeles, California 90095, USA.Author: Ming Yan, Juanjuan Du, Zhen Gu, Min Liang, Yufang Hu, Wenjun Zhang, Saul Priceman, Lily Wu, Z. Hong ...
https://www.researchgate.net/publication/40028951_A_novel_intracellular_protein_delivery_platform_based_on_single-protein_nanocapsules
A novel intracellular protein delivery platform based on single-protein nanocapsules Article (PDF Available) in Nature Nanotechnology 5(1):48-53 · November 2009 …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451076/
Protein delivery platforms are important tools in the development of novel protein therapeutics and biotechnologies. We have developed a new class of protein delivery agent based on sub-micrometer-sized Cry3Aa protein crystals that naturally form within the bacterium Bacillus thuringiensis.We demonstrate that fusion of the cry3Aa gene to that of various reporter proteins allows for the facile ...Author: Manoj S. Nair, Marianne M. Lee, Astrid Bonnegarde-Bernard, Julie A. Wallace, Donald H. Dean, Michael...
http://adsabs.harvard.edu/abs/2010NatNa...5...48Y
However, the effectiveness of this method has been limited by its low delivery efficiency and poor stability against proteases in the cell, which digest the protein. Here, we show a novel delivery platform based on nanocapsules consisting of a protein core and a thin permeable polymeric shell that can be engineered to either degrade or remain ...
https://www.sciencedirect.com/science/article/pii/S0168365918302530
These results demonstrate that our novel, useful platform for intracellular and tumor-targeted delivery of enzymes can be used to develop potent anticancer therapeutics, harnessing a variety of anti-proliferative proteins and enzymes to act on intracellular targets in a tumor-specific manner.Author: Kyoung Ran Kim, Dohyeon Hwang, Juhyeon Kim, Chang Yong Lee, Wonseok Lee, Dae Sung Yoon, Dongyun Shin...
https://www.pnas.org/content/110/6/2082
Feb 05, 2013 · nanoparticle delivery; Intracellular delivery of macromolecules is a critical step in therapeutic and research applications. Nanoparticle-mediated delivery of DNA and RNA, for example, is being explored for gene therapy (1, 2), while protein delivery is a promising means of affecting cellular function in both clinical and laboratory settings.Author: Armon Sharei, Janet Zoldan, Andrea Adamo, Woo Young Sim, Nahyun Cho, Emily Jackson, Shirley Mao, Sab...
https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.201906187?af=R
Protein therapy offers promising prospects for the treatment of various important diseases, thus it is highly desirable to develop a robust carrier that can deliver active proteins into cells. The development of a novel protein delivery platform based on the self‐assembly of multiarmed amphiphilic cyclodextrins (CDEH) is reported.Author: Xiao He, Qipeng Long, Zhiying Zeng, Lan Yang, Yaqin Tang, Xuli Feng
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