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https://pubs.rsc.org/en/content/articlelanding/2010/cc/b916911c#!
A therapeutic aptamer conjugated liposome drug delivery system which delivered loaded drug to target cells with high specificity and excellent efficiency was prepared and characterized.
http://www.rsc.org/suppdata/CC/b9/b916911c/b916911c.pdf
A Liposome-based Nanostructure for Aptamer Directed Delivery Huaizhi Kang, Meghan B. O'Donoghue, Haipeng Liu and Weihong Tan* Center for Research at the Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics Shands Cancer Center and UF Genetics Institute, McKnight Brain Institute, University of Florida,
https://www.researchgate.net/publication/40731831_A_liposome-based_nanostructure_for_aptamer_directed_delivery
For example, aptamer AS1411 targets nucleolin in MCF-7 cells [15], aptamer-liposome conjugates containing aptamer sgc8 has been used for drug delivery into CEM-CCRF leukemia cells …
https://pubs.acs.org/doi/abs/10.1021/ja070748i
Nov 14, 2007 · A liposome-based nanostructure for aptamer directed delivery. Chemical Communications 2010 , 46 (2) , 249. DOI: 10.1039/b916911c.Author: Sang-Min Lee, Haimei Chen, Christine M. Dettmer, Thomas V. O'Halloran, SonBinh T. Nguyen
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218254/
A cell-permeable sgc8-PEG-liposome nanostructure has also been reported for drug delivery . With approximately 250 aptamers on each liposome, this design leads to multiple aptamer-receptor interactions, provides better binding to the target cells, and facilitates translocation through the plasmic membrane.Author: Weihong Tan, Weihong Tan, Hui Wang, Yan Chen, Yan Chen, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoy...
https://www.nature.com/articles/emm201644
May 06, 2016 · The intercalating properties of nucleic acid aptamers mean that they are selective and sensitive delivery vehicles. On the basis of the fact that doxorubicin, an anti-cancer drug, can easily intercalate into an A10 aptamer that recognizes prostate-specific membrane antigen (PSMA),...Author: Hunho Jo, Changill Ban
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043981/
Oct 30, 2010 · Most recent work from the Tan lab has provided an aptamer-modified liposome system for exploiting an anti-PTK7 aptamer as a promising drug delivery vehicle (Kang et al., 2010). In this example, the sgc8 aptamer was chemically linked to the liposome by a PEG spacer, resulting in enhanced stability compared with plain liposomes.Author: Jiehua Zhou, John J. Rossi
https://www.nature.com/articles/am201412
Apr 11, 2014 · Liposomes are the most clinically established nanosystems for drug delivery. The improved specificity and efficacy of aptamer-guided liposome delivery systems were confirmed by Kang et al., 29 who...Author: Qiaoling Liu, Qiaoling Liu, Chen Jin, Yanyue Wang, Xiaohong Fang, Xiaobing Zhang, Zhuo Chen, Weihong...
https://www.nature.com/articles/srep10099
May 11, 2015 · Working principle of aptamer-based dendritic DNA nanostructure. The final generation Dox-G 3-sgc8 is designed with various functional groups, including fluorophores, targeting ligands and anticancer drugs to endow the DNA dendrimer with the capability of cancer cell …Author: Huimin Zhang, Yanli Ma, Yi Xie, Yuan An, Yishun Huang, Zhi Zhu, Chaoyong James Yang
https://www.sciencedirect.com/science/article/pii/S0167779911001132
A cell-permeable sgc8–PEG–liposome nanostructure has also been reported for drug delivery . With approximately 250 aptamers on each liposome, this design leads to multiple aptamer–receptor interactions, provides better binding to the target cells and facilitates translocation through the plasmic membrane.Author: Weihong Tan, Weihong Tan, Hui Wang, Yan Chen, Yan Chen, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoy...
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