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http://www.hughesmedicine.com/2014/07/piperacillin-tazobactam-zosyn-extended.html#:~:text=At%2035%20mL%2Fmin%20%28or%20any%20creatinine%20clearance%20%3E20,piperacillin-tazobactam%20is%20about%201%20hour%20in%20healthy%20subjects.
https://allnurses.com/zosyn-hrs-t342028/
Recently our hospital has changed protocol to infuse 3.375GM with 100mL of NS over 4 hrs. At first it was just for renal patients with off the wall BUN/Creatine levels, now it is protocol for every patient receiving Zosyn. They say that …
http://www.hughesmedicine.com/2014/07/piperacillin-tazobactam-zosyn-extended.html
3.375 g given over 4 hours has a high probability to achieve the desired time over the MIC when: Dosed every 8 hours for creatinine clearance 20 mL/min or greater Dosed every 12 hours for lower clearances (including hemodialysis)
https://psichologyanswers.com/library/lecture/read/69202-why-is-zosyn-infused-over-4-hours
Why is zosyn infused over 4 hours? Summary: EI β-lactam therapy is now considered a key aspect of antimicrobial stewardship, and published evidence indicates that i.v. infusion of piperacillin-tazobactam over extended periods (e.g., four hours) instead of the traditionally recommended 30 minutes may offer several advantages, including reduced ...
https://www.pfizermedicalinformation.com/en-us/zosyn/dosage-admin
2.1 Important Administration Instructions. If a dose of ZOSYN is required that does not …
https://med.stanford.edu/content/dam/sm/bugsanddrugs/documents/antimicrobial-dosing-protocols/SHC-Extended-Infusion-Piperacillin-Tazobactam.pdf
prolonged-infusion Zosyn® and compared intermittent 30-minute infusions of 3.375–4.5 g Q 6–8H with prolonged 4-hour infusions of 3.375 g Q8H. 13 …
https://www.pdr.net/drug-summary/Zosyn-piperacillin-tazobactam-629
3.375 g (3 g piperacillin and 0.375 g tazobactam) administered over 4 hours IV every 8 hours or 4.5 g (4 g piperacillin and 0.5 g tazobactam) administered over 4 hours IV every 8 hours.[57817] [61791] [61792] [61793] [61999] [62000] [64955] [64956] [64957] [64958]
https://pubmed.ncbi.nlm.nih.gov/21817083/
Summary: EI β-lactam therapy is now considered a key aspect of antimicrobial stewardship, and published evidence indicates that i.v. infusion of piperacillin-tazobactam over extended periods (e.g., four hours) instead of the traditionally recommended 30 minutes may offer several advantages, including reduced mortality and length of hospital stay and lower treatment cost. …
https://dig.pharmacy.uic.edu/faqs/2019-2/august-2019-faqs/update-does-extended-infusion-piperacillin-tazobactam-zosyn-improve-clinical-outcomes/
The clinical efficacy of extended-infusion piperacillin-tazobactam was described in a retrospective case series of 50 children. 13 Piperacillin-tazobactam was administered over 4 hours at a median dose of 111.4 mg/kg every 8 hours. The median age was 5 years.
https://www.uspharmacist.com/article/prolongedinfusion-dosing-of-betalactam-antibiotics
For patients with preserved renal function (creatinine clearance [CrCl] >20 mL/min) or on continuous renal replacement therapy, a dose of 3.375 g every 8 hours (4-hour infusion) may be considered equivalent to 4.5 g every 6 hours (30-minute infusion).
http://ugotabug.med.miami.edu/documents/ExtendedPipTazo.pdf
• Daily dose generally 3.375 grams IV q6h over 30 minutes o Extended infusion (infused over 4 hours) • Plasma levels maintained above the MIC more consistently as compared to intermittent • Requires extended time of line use, however provides sufficient line-free intervals for infusion of other medications
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