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https://allnurses.com/zosyn-hrs-t342028/#:~:text=Recently%20our%20hospital%20has%20changed%20protocol%20to%20infuse,the%20therapeutic%20levels%20stay%20in%20the%20system%20longer.
https://allnurses.com/zosyn-hrs-t342028/
Recently our hospital has changed protocol to infuse 3.375GM with 100mL of NS over 4 hrs. At first it was just for renal patients with off the wall BUN/Creatine levels, now it is protocol for every patient receiving Zosyn. They say that …
https://www.pfizermedicalinformation.com/en-us/zosyn/dosage-admin
2.1 Important Administration Instructions. If a dose of ZOSYN is required that does not …
https://med.stanford.edu/content/dam/sm/bugsanddrugs/documents/antimicrobial-dosing-protocols/SHC-Extended-Infusion-Piperacillin-Tazobactam.pdf
Zosyn® was best achieved with a 4-hour infusion of 3.375g IV Q8H.2,3 (see Appendix: Figure 5). 2. In 2007, a hospital-wide substitution program where intermittently infused Zosyn ® …
http://www.hughesmedicine.com/2014/07/piperacillin-tazobactam-zosyn-extended.html
At a creatinine clearance of 100 mL/min, the 3.375 g every 8 hours over a 4 hour infusion was found to have a comparable attainment of target as 3.375 g every 12 hours at 20 mL/min. Presumably, even lower clearances could only have improved target attainment as would increasing the infusion time.
https://www.pdr.net/drug-summary/Zosyn-piperacillin-tazobactam-629
Data are very limited. 100 mg/kg/dose piperacillin component (112.5 mg/kg/dose piperacillin; tazobactam) administered over 4 hours IV every 8 hours (Max: 4 g/dose piperacillin [4.5 g/dose piperacillin; tazobactam]).[53623] Start within 1 hour for septic shock or within 3 hours for sepsis-associated organ dysfunction without shock.
http://aspiruslibrary.org/guidelines_new/ID/AWH%20EI%20Piperacillin-Tazobactam%20Draft%20Protocol%209%2019%202016.pdf
o 3.375g q8h (4 hour infusion): >90% for MICs up to 16 mg/L • The extended 4 hour infusion of PTZ 3.375g IV every 8 hours achieved a PTA > 90% for …
https://pubmed.ncbi.nlm.nih.gov/21817083/
Summary: EI β-lactam therapy is now considered a key aspect of antimicrobial stewardship, and published evidence indicates that i.v. infusion of piperacillin-tazobactam over extended periods (e.g., four hours) instead of the traditionally recommended 30 minutes may offer several advantages, including reduced mortality and length of hospital stay and lower treatment cost. …
https://dig.pharmacy.uic.edu/faqs/2019-2/august-2019-faqs/update-does-extended-infusion-piperacillin-tazobactam-zosyn-improve-clinical-outcomes/
The clinical efficacy of extended-infusion piperacillin-tazobactam was described in a retrospective case series of 50 children. 13 Piperacillin-tazobactam was administered over 4 hours at a median dose of 111.4 mg/kg every 8 hours. The median age was 5 years.
https://globalrph.com/dilution/piperacillin-tazo-zosyn/
The usual daily dose of Zosyn for adults is 3.375 g every six hours. Initial presumptive treatment of patients with nosocomial pneumonia should start with Zosyn at a dosage of 4.5 g every six hours plus an aminoglycoside, totaling 18.0 …
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