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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · There are different viral and nonviral vectors for gene delivery, but all gene therapy applications depend on the fact that the genetic material needs to be delivered across the cell membrane and ultimately to the cell nucleus.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293995/
Introduction: Viruses as Vectors for Therapeutic Gene Delivery. The idea to treat human disease by delivering a therapeutic gene was first conceived as early as the 1970s (Friedmann and Roblin, 1972).The potential of viruses as vectors for gene delivery was recognized even then.Author: Thomas B. Lentz, Steven James Gray, R. Jude Samulski
https://www.nature.com/articles/nrn1104
May 01, 2003 · The use of viral vectors to deliver genes to the nervous system shows great promise for both basic research and therapeutic applications. However, the brain presents a …Author: Beverly L. Davidson, Xandra O. Breakefield
https://seekingalpha.com/article/4305556-gene-therapy-series-2-delivery-systems-in-gene-therapy-including-viral-vectors
Nov 11, 2019 · Continuing with the series of articles on gene therapy, this article will discuss the various delivery methods for gene therapies with a focus on viral vectors.The article also discusses the classific
https://www.sciencedirect.com/science/article/pii/S0378595519305672
Gene therapy using virus vectors to treat hereditary diseases has made remarkable progress in the past decade. There are FDA-approved products for ex-vivo gene therapy for diseases such as immunodeficiencies (e.g., SCID), and in vivo gene therapy for a rare blindness and neuro-muscular disease. Gene therapy for hereditary hearing loss has picked up pace in the past five years due to …Author: Casey A. Maguire, David P. Corey
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
Gene delivery systems include viral vectors and non-viral vectors. Viral vectors are the most effective, but their application is limited by their immunogenicity, oncogenicity and the small size of the DNA they can transport. Non-viral vectors are safer, of low cost, more reproducible and do not present DNA size limit.Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/viral-vector-gene-delivery
Nonviral vectors use a variety of lipid formulations to deliver DNA to host cells. Although this approach is technically simpler than the development of viral vectors, gene delivery by nonviral vectors is relatively inefficient compared with viral vector-mediated gene transfer, and transgene expression is highly variable and generally short-lived.
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