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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · The transfer of genetic material through an appropriate vector, which can be a viral or nonviral vector, into the target tissue is in vivo delivery. This technique is the least advanced strategy at present but potentially it might be the most useful.
https://www.nature.com/articles/s41573-019-0012-9
Feb 01, 2019 · Adeno-associated virus (AAV) vectors are the leading platform for gene delivery for the treatment of a variety of human diseases. Recent advances in developing clinically desirable AAV capsids, optimizing genome designs and harnessing revolutionary biotechnologies have contributed substantially to the growth of the gene therapy field.Author: Dan Wang, Phillip W. L. Tai, Guangping Gao
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509525/
General introduction to CNS gene therapy. The use of viral vectors to deliver genes to patients affected with neurological disorders is an attractive concept to researchers and clinicians. Since the sequencing of the human genome, opportunities to correct genetic imbalances seem to be at our fingertips; however, many hurdles remain before DNA can be used as a drug.Author: Steven J Gray, Kenton T Woodard, R Jude Samulski
https://apps.dtic.mil/dtic/tr/fulltext/u2/a435958.pdf
The use of viruses, for example adenovirus, vaccinia virus, and Venezuelan equine encephalitis virus, as vaccine vectors has enabled researchers to develop effective means for countering the threat of bioterrorism and biowarfare. An overview of the different viral vectors …Author: John S. Lee, Angela G. Hadjipanayis, Michael D. Parker
https://www.tandfonline.com/doi/abs/10.1080/17425247.2019.1641083
Jun 20, 2019 · Furthermore, hybrid systems with a combination of vectors or drugs have been recently applied as new trends in gene therapy. Expert opinion: Although aerosol gene delivery has many advantages, physiological barriers in the lungs pose formidable challenges. Targeted gene delivery and gene-editing technology are promising strategies for lung cancer therapy.Author: Ah Young Lee, Myung-Haing Cho, Sanghwa Kim
https://www.grandviewresearch.com/industry-analysis/drug-gene-delivery-devices-market
Viral vectors currently dominate the gene delivery systems market with 4 approved drugs. More than 60% of the ongoing clinical trials on gene therapies are based on the viral vectors for transfection. Thus, the viral segment is expected to remain dominant throughout the forecast period.
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