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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293995/
Retroviral vectors are currently the second most commonly used viral vector for gene delivery to the CNS. Ex vivo transduction of cells with a Moloney leukemia virus vector expressing nerve growth factor (NGF) and introduction to the brain has been used in treatment of Alzheimer’s disease with moderate success ( Tuszynski et al., 2005 ).Author: Thomas B. Lentz, Steven James Gray, R. Jude Samulski
https://www.sciencedirect.com/science/article/pii/S0969996111003275
Retroviral vectors are currently the second most commonly used viral vector for gene delivery to the CNS. Ex vivo transduction of cells with a Moloney leukemia virus vector expressing nerve growth factor (NGF) and introduction to the brain has been used in treatment of Alzheimer's disease with moderate success ( Tuszynski et al., 2005 ).Author: Thomas B. Lentz, Steven James Gray, R. Jude Samulski
https://www.ncbi.nlm.nih.gov/pubmed/22001604
Viral vectors for gene delivery to the central nervous system. Lentz TB(1), Gray SJ, Samulski RJ. Author information: (1)Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7352, USA.Author: Thomas B. Lentz, Steven James Gray, R. Jude Samulski
https://www.sciencedirect.com/science/article/abs/pii/S0969996111003275
Viral vectors for gene delivery to the central nervous system. ... At the forefront of potential vectors, viral systems have evolved to efficiently deliver their genetic material to a cell. The biology of different viruses offers unique solutions to the challenges of gene therapy, such as cell targeting, transgene expression and vector ...Author: Thomas B. Lentz, Steven James Gray, R. Jude Samulski
https://www.nature.com/articles/nrn1104
May 01, 2003 · The use of viral vectors to deliver genes to the nervous system shows great promise for both basic research and therapeutic applications. However, the brain presents a challenging target for gene delivery, because of its complex structure, compartmentalized functions and …Author: Beverly L. Davidson, Xandra O. Breakefield
https://www.researchgate.net/publication/51723556_Viral_Vectors_for_Gene_Delivery_to_the_Central_Nervous_System
In this regard, non-viral gene delivery systems such as electroporation, lipofection, and nucleofection can be associated with membrane damage and high cell loss, considerable expense, and low transfection success [4, 5]. Viral vectors such as adenoviruses, lentiviruses,...
https://houptlab.org/courses/cmn/transgenic/Davidson2003.pdf
efficiency of gene delivery by virus vectors. The spectrum of vectors used in basic research applications surpasses the few being used in clinical trials,and comprises those with simple capsid virions VIRAL VECTORS FOR GENE DELIVERY TO THE NERVOUS SYSTEM Beverly L. Davidson* and Xandra O. Breakefield ‡
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509525/
Adeno-associated virus (AAV) is the most utilized vector for CNS gene delivery due to its favorable safety profile, long-term expression, and ability to target neurons and glia. Lentiviral vectors are emerging as viable tools for therapeutic CNS gene delivery, with a larger packaging capacity compared with AAV vectors.Author: Steven J Gray, Kenton T Woodard, R Jude Samulski
https://www.sciencedirect.com/science/article/pii/S1046202302002220
The use of viral vectors as agents for gene delivery provides a direct approach to manipulate gene expression in the mammalian central nervous system (CNS). The present article describes in detail the methodology for the injection of viral vectors, in particular adeno-associated virus (AAV) vectors, into the adult rat brain and spinal cord to obtain reproducible and successful transduction of neural tissue.Author: Marc J Ruitenberg, Ruben Eggers, Gerard J Boer, Joost Verhaagen
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