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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · There are different viral and nonviral vectors for gene delivery, but all gene therapy applications depend on the fact that the genetic material needs to be delivered across the cell membrane and ultimately to the cell nucleus.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293995/
The potential of viruses as vectors for gene delivery was recognized even then. Viruses are among the simplest biological agents capable of delivering genetic information to a cell and have evolved properties that make them useful as vectors for gene delivery (Shen and Post, 2007). Structural virions carry and protect viral genetic information ...Author: Thomas B. Lentz, Steven James Gray, R. Jude Samulski
https://seekingalpha.com/article/4305556-gene-therapy-series-2-delivery-systems-in-gene-therapy-including-viral-vectors
Nov 11, 2019 · Non-viral methods of transgene delivery. Although viral vectors are being used in two-third of gene therapy programs, there are some non-viral methods of …
https://www.nature.com/articles/nrn1104
May 01, 2003 · The use of viral vectors to deliver genes to the nervous system shows great promise for both basic research and therapeutic applications. However, the brain presents a …Author: Beverly L. Davidson, Xandra O. Breakefield
http://www.vigenebio.com/
Excellence in Viral Vector-based Gene Delivery. Explore our plasmid manufacturing services > Vigene Joins the Fight Against COVID-19 > AAV. ... AAV vectors generated from this scalable and efficient platform have been proven to infect and transduce a myriad of mammalian cell lines in vitro and a broad range of cell types in vivo.
http://www.genetherapynet.com/viral-vectors.html
The concept of gene therapy seems straightforward, but this is clearly an oversimplification, and numerous problems and risks exist that prevent gene therapy using viral vectors. Viruses can usually infect more than one type of cell.
https://www.genomics-online.com/resources/16/5012/viral-gene-delivery-vectors/
Adeno-Associated Viral (AAV) vectors have many of the same advantages as adenoviral vectors. High expression, very high viral titer, and a moderate quantity of mRNA and protein expression are all advantages associated with AAV vectors. Weaknesses: Like the adenoviral expression system, AAV gene delivery is most commonly transient.
https://www.sciencedirect.com/science/article/pii/S0378595519305672
Gene therapy using virus vectors to treat hereditary diseases has made remarkable progress in the past decade. There are FDA-approved products for ex-vivo gene therapy for diseases such as immunodeficiencies (e.g., SCID), and in vivo gene therapy for a rare blindness and neuro-muscular disease. Gene therapy for hereditary hearing loss has picked up pace in the past five years due to …Author: Casey A. Maguire, David P. Corey
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