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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · Keywords: Chemical delivery, gene therapy, non viral delivery systems, physical delivery, viral delivery systems INTRODUCTION Basically gene therapy is an intracellular delivery of genomic materials (transgene) into specific cells to generate a therapeutic effect by correcting an existing abnormality or providing the cells with a new function.[ 1 ]
https://www.takarabio.com/learning-centers/gene-function/viral-transduction/recombinant-virus-comparison
Viral gene delivery systems Viral gene delivery allows the introduction and expression of a gene of interest in almost any mammalian cell type. However, selecting the best viral gene delivery system for your experimental aim can be challenging.
https://www.sciencedirect.com/topics/neuroscience/viral-gene-delivery-system
Viral Gene Delivery Viral gene delivery uses one of many available viral vectors to deliver DNA to cells in vitro or in vivo . A virus can be thought of as a tiny molecular machine whose entire purpose is to attach to cells and inject genetic material.
https://www.intechopen.com/books/recent-advances-in-novel-drug-carrier-systems/gene-delivery-systems-recent-progress-in-viral-and-non-viral-therapy
Chemical methods use natural and synthetic compounds are to deliver the gene into the cell. The gene delivery system generally includes polymers, liposomes, dendrimers, and cationic lipids. Non-viral vectors have many advantages, such as easy of synthesis, effective …Author: Erdal Cevher, Ali Demir Sezer, Emre Şefik Çağlar
https://seekingalpha.com/article/4305556-gene-therapy-series-2-delivery-systems-in-gene-therapy-including-viral-vectors
Nov 11, 2019 · Examples include AAV, adenovirus, and herpesvirus. Two of the most commonly used viruses as vectors in gene therapy include adeno-associated virus (AAV) and lentiviruses (LV). AAV-based transgene...
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
Gene delivery systems include viral vectors and non-viral vectors. Viral vectors are the most effective, but their application is limited by their immunogenicity, oncogenicity and the small size of the DNA they can transport. Non-viral vectors are safer, of low cost, more reproducible and do not present DNA size limit.Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356701/
Jan 04, 2019 · None of the trials currently registered on clinicaltrials.gov use viral delivery systems in combination with CRISPR/Cas9 . However, there are currently 44 completed and 98 active clinical trials with AAV, mostly gene augmentation therapy to treat diseases caused by loss-of-function mutations.Author: Christine L. Xu, Merry Z. C. Ruan, Vinit B. Mahajan, Stephen H. Tsang
https://biomaterialsres.biomedcentral.com/articles/10.1186/s40824-019-0156-z
Mar 12, 2019 · The viral gene delivery systems have discussed for the viral vectors based on DNA, RNA, and oncolytic viral vectors, respectively. The non-viral gene delivery systems have also treated for the physicochemical approaches such as physical method and chemical method.Author: YK Sung, SW Kim
https://www.slideshare.net/Aparajitha_Anne/gene-delivery-system
May 19, 2012 · Inorganic Nanoparticles:It one of the non-viral gene delivery system where we use gold .silicaand iron oxide and calcium phosphate some of the benefits are storagestability, low manufacturing cost and often time, low immunogenicity.
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