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https://www.sciencedirect.com/science/article/pii/S0076687904920095
Designing the Short Hairpin RNA (shRNA) Expression Cassette. Viral vectors are generated from shuttle vectors, containing the expression cassette of interest and plasmids required for vector production (see Fig. 2). PCR-based methodology allows construction of a universal shRNA expression cassette for eventual expression from lentivirus, AAV, or Ad.Author: Beverly L. Davidson, Scott Q. Harper
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949849/
Sep 21, 2010 · The design of viral RNAi vectors became possible upon discovering that promoter-driven expression of short hairpin RNAs (shRNAs) induces the RNAi machinery . This strategy involves cloning an oligonucleotide containing the siRNA sequence into plasmid or viral vectors to endogenously express shRNA, which is subsequently processed in the cytoplasm to siRNA.Author: Katja Sliva, Barbara S Schnierle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789654/
Jul 25, 2009 · Recombinant lentivirus-delivered short hairpin RNAs targeted to conserved coxsackievirus sequences protect against viral myocarditis and improve survival rate in an animal model. Virus Genes. 2008; 36 :141–146.Author: N. Manjunath, Haoquan Wu, Sandesh Subramanya, Premlata Shankar
https://www.sciencedirect.com/science/article/pii/S0169409X0900060X
RNA interference (RNAi) was first recognized as a natural antiviral defense mechanism in plants wherein long double-stranded RNAs generated during viral replication are cleaved by the enzyme Dicer into short 21–23 nucleotide double-stranded RNA molecules called small interfering RNAs (siRNAs) that mediate sequence-specific gene silencing , .Author: N. Manjunath, Haoquan Wu, Sandesh Subramanya, Premlata Shankar
https://www.pnas.org/content/102/3/773
Jan 18, 2005 · First, in the context of an established infection, viral RNAs may be protected within complexes or nucleocapsid structures as has been reported for hepatitis D virus (1), Rous sarcoma virus (12), and respiratory syncytial virus (RSV) (13).Author: Susan L. Uprichard, Bryan Boyd, Alana Althage, Francis V. Chisari
https://www.researchgate.net/publication/46392655_Selective_gene_silencing_by_viral_delivery_of_short_hairpin_RNA
Selective gene silencing by RNAi can be achieved essentially by two nucleic acid based methods: i) cytoplasmic delivery of short double-stranded (ds) interfering RNA oligonucleotides (siRNA ...
https://en.wikipedia.org/wiki/Small_interfering_RNA
The resulting transcript is a short hairpin RNA (shRNA), which can be processed into a functional siRNA by Dicer in its usual fashion. Typical transcription cassettes use an RNA polymerase III promoter (e.g., U6 or H1) to direct the transcription of small nuclear RNAs (snRNAs) (U6 is involved in gene splicing ; H1 is the RNase component of ...
https://cancerres.aacrjournals.org/content/70/7/2571
Apr 01, 2010 · The dynamic properties of RNA interference (RNAi) in cancer biology have led investigators to pursue with significant interest its role in tumorigenesis and cancer therapy. We recently reported that decreased expression of key RNAi enzymes, Dicer and Drosha, in epithelial ovarian cancers was associated with poor clinical outcome in patients.Author: William M. Merritt, Menashe Bar-Eli, Anil K. Sood
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