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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · There are different viral and nonviral vectors for gene delivery, but all gene therapy applications depend on the fact that the genetic material needs to be delivered across the cell membrane and ultimately to the cell nucleus.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782077/
Oct 16, 2009 · Insertional mutagenesis is also a potential issue for some viral vectors that integrate foreign DNA into the genome. The nonviral gene delivery methods, on the other hand, use synthetic or natural compounds or physical forces to deliver a piece of DNA into a cell.Author: Mohammed S. Al-Dosari, Xiang Gao
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347098/
Jan 01, 2015 · The optimal vector and delivery system depends on the target cells and its characteristics, duration of expression and the size of the genetic material to be incorporated in the vector [3,4].The present vectors used for gene therapy are broadly classified as Viral vectors, Non-viral vectors and engineered vectors. The non-viral vectors are Naked DNA, particle based and …Author: Murali Ramamoorth, Aparna Narvekar
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814977/
Gene Therapy Delivery Systems for Enhancing Viral and Nonviral Vectors for Cardiac Diseases: Current Concepts and Future Applications. Sanger Heart and Vascular Institute, Cannon Research Center, Carolinas HealthCare System, Charlotte, NC 28203.Author: Michael G. Katz, Anthony S. Fargnoli, Richard D. Williams, Charles R. Bridges
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
Gene delivery systems include viral vectors and non-viral vectors. Viral vectors are the most effective, but their application is limited by their immunogenicity, oncogenicity and the small size of the DNA they can transport. Non-viral vectors are safer, of …Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
https://www.nature.com/articles/nrg3763
Jul 15, 2014 · Non-viral vectors for gene-based therapy. Hao Yin Hao Yin is a postdoctoral associate at Massachusetts Institute of Technology, Cambridge, USA. He received his B.S. in biochemistry at Nanjing University, China, and his Ph.D. in toxicology from the School of Pharmacy, University of Colorado Anschutz Medical Campus, Aurora, USA.Author: Hao Yin, Rosemary L. Kanasty, Ahmed A. Eltoukhy, Arturo J. Vegas, Arturo J. Vegas, J. Robert Dorkin,...
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