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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182016/
May 23, 2011 · Vaults Engineered for Hydrophobic Drug Delivery. ... We engineered recombinant vaults to encapsulate the highly insoluble and toxic hydrophobic compound All-trans Retinoic Acid (ATRA) using a vault binding lipoprotein complex that forms a lipid bilayer nanodisk. These recombinant vaults offer protection to the encapsulated ATRA from external ...Author: Daniel C. Buehler, Daniel B. Toso, Valerie A. Kickhoefer, Z. Hong Zhou, Leonard H. Rome
https://www.researchgate.net/publication/51063846_Vaults_Engineered_for_Hydrophobic_Drug_Delivery
In this review, we primarily aim to provide a summary of polymeric and non-polymeric genetically engineered drug carriers, and focus on their drug-delivery applications using various ...
https://www.ncbi.nlm.nih.gov/pubmed/21506266
May 23, 2011 · Vaults engineered for hydrophobic drug delivery. Buehler DC(1), Toso DB, Kickhoefer VA, Zhou ZH, Rome LH. Author information: (1)Department of Biological Chemistry, David Geffen School of Medicine, 615 Charles E. Young Drive South, University of California-Los Angeles, CA 90095, USA.Author: Daniel C. Buehler, Daniel B. Toso, Valerie A. Kickhoefer, Z. Hong Zhou, Leonard H. Rome
http://onlinelibrary.wiley.com/doi/10.1002/smll.201002274/abstract
May 19, 2011 · These properties make vaults an ideal candidate for development into a drug delivery vehicle. In this study, the first example of using vaults towards this goal is reported. Recombinant vaults are engineered to encapsulate the highly insoluble and toxic hydrophobic compound all‐ trans retinoic acid (ATRA) using a vault‐binding lipoprotein ...
https://onlinelibrary.wiley.com/doi/pdf/10.1002/smll.201002274
Highly conserved and almost ubiquitously expressed in eukaryotes, vaults form a large nanocapsule with a barrel‐shaped morphology surrounding a large hollow interior. These properties make vaults an ideal candidate for development into a drug delivery vehicle. In this study, the first example of using vaults towards this goal is reported.Author: Daniel C. Buehler, Daniel B. Toso, Valerie A. Kickhoefer, Z. Hong Zhou, Leonard H. Rome
http://europepmc.org/articles/PMC4182016
May 01, 2011 · Thus, recombinant vaults are an attractive target for engineering as a platform for drug delivery. With the goal of creating a vault capable of encapsulating therapeutic compounds for drug delivery, we have designed a strategy to package another …
https://www.researchgate.net/publication/51148963_Drug_Delivery_Vaults_Engineered_for_Hydrophobic_Drug_Delivery_Small_102011
For more information, please read the Full Paper “Vaults Engineered for Hydrophobic Drug Delivery” by L. H. Rome and co-workers, beginning on page 1431. Do you want to read the rest of this ...
https://pubs.acs.org/doi/10.1021/nn5002694
We report a novel approach to a new class of bioengineered, monodispersed, self-assembling vault nanoparticles consisting of a protein shell exterior with a lipophilic core interior designed for drug and probe delivery. Recombinant vaults were engineered to contain a small amphipathic α-helix derived from the nonstructural protein 5A of hepatitis C virus, thereby creating within the vault ...Author: Daniel C. Buehler, Matthew D. Marsden, Sean Shen, Daniel B. Toso, Xiaomeng Wu, Joseph A. Loo, Z. Hon...
https://www.sciencedaily.com/releases/2011/04/110421141646.htm
Apr 23, 2011 · The ability to encapsulate therapeutic compounds into the vault is a critical and fundamental obstacle in their development for small-molecule drug …
https://vaultpharma.com/platform/
Further, vaults can be engineered to contain exogenous materials (proteins, cytokines, antigens etc.). Ubiquitous throughout the human body, vaults are bio-invisible to the human immune system. This makes vault technology a perfect delivery platform unlike viruses and most synthetic drug delivery technologies that have serious safety complications.
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