Vault Drug Delivery

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Latest Advances in the Development of Eukaryotic Vaults as ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680493/
    Jun 28, 2019 · The use of smart drug delivery systems (DDSs) is one of the most promising approaches to overcome some of the drawbacks of drug-based therapies, such as improper biodistribution and lack of specific targeting. ... delivery. The vault is being explored and used as a tool to modulate the activity of the immune system. Vault Pharma’s technology ...Author: Amanda Muñoz-Juan, Aida Carreño, Rosa Mendoza, José L. Corchero

Vaults engineered for hydrophobic drug delivery.

    https://www.ncbi.nlm.nih.gov/pubmed/21506266
    May 23, 2011 · Vaults engineered for hydrophobic drug delivery. Buehler DC(1), Toso DB, Kickhoefer VA, Zhou ZH, Rome LH. Author information: (1)Department of Biological Chemistry, David Geffen School of Medicine, 615 Charles E. Young Drive South, University of California-Los Angeles, CA 90095, USA.Author: Daniel C. Buehler, Daniel B. Toso, Valerie A. Kickhoefer, Z. Hong Zhou, Leonard H. Rome

Bioengineered Vaults: Self-Assembling Protein Shell ...

    https://pubs.acs.org/doi/10.1021/nn5002694
    We report a novel approach to a new class of bioengineered, monodispersed, self-assembling vault nanoparticles consisting of a protein shell exterior with a lipophilic core interior designed for drug and probe delivery. Recombinant vaults were engineered to contain a small amphipathic α-helix derived from the nonstructural protein 5A of hepatitis C virus, thereby creating within the vault ...Author: Daniel C. Buehler, Matthew D. Marsden, Sean Shen, Daniel B. Toso, Xiaomeng Wu, Joseph A. Loo, Z. Hon...

Nanoscale Vaults Engineered to Encapsulate 'nanodisks' for ...

    https://www.medindia.net/news/nanoscale-vaults-engineered-to-encapsulate-nanodisks-for-drug-delivery-84073-1.htm
    With the goal of creating a vault capable of encapsulating therapeutic compounds for drug delivery, UCLA doctoral student Daniel Buhler designed a strategy to package another nanoparticle, known ...

Bioengineered Vaults: Self-Assembling Protein Shell ...

    https://pubs.acs.org/doi/pdf/10.1021/nn5002694
    lipophilic compounds of interest for vault-mediated drug delivery (Figure 1C). RESULTS AND DISCUSSION Amphipathic r-Helix Vault as a Self-Assembling Protein Shell Lipophilic Core Complex. Development of the vault as a potentially viable drug delivery system is moti-vated by the particles' inherent advantages: small

Scientists engineer nanoscale vaults to encapsulate ...

    https://www.sciencedaily.com/releases/2011/04/110421141646.htm
    Apr 23, 2011 · With the goal of creating a vault capable of encapsulating therapeutic compounds for drug delivery, UCLA doctoral student Daniel Buhler designed a …

Scientists engineer nanoscale vaults to encapsulate ...

    https://www.nextbigfuture.com/2011/04/scientists-engineer-nanoscale-vaults-to.html
    A vault is essentially barrel-shaped nanocapsule with a large, hollow interior — properties that make them ripe for engineering into a drug-delivery vehicles. The ability to encapsulate small-molecule therapeutic compounds into vaults is critical to their development for drug delivery.

Vaults Engineered for Hydrophobic Drug Delivery - Buehler ...

    https://onlinelibrary.wiley.com/doi/pdf/10.1002/smll.201002274
    Finally, these ATRA‐loaded vaults show enhanced cytotoxicity against the hepatocellular carcinoma cell line HepG2. The ability to package therapeutic compounds into the vault is an important achievement toward their development into a viable and versatile platform for drug delivery.Author: Daniel C. Buehler, Daniel B. Toso, Valerie A. Kickhoefer, Z. Hong Zhou, Leonard H. Rome

List of Careers Career Options & Choices Vault.com

    https://www.vault.com/best-jobs-and-career-guidance
    Discover the best profession for your skills and interests with in-depth profession overviews. Gain insight on the main duties of each profession, the work environment, training requirements, advancement prospects and more. Vault partners with thousands of colleges, universities and academic ...

Latest Advances in the Development of Eukaryotic Vaults as ...

    https://www.mdpi.com/1999-4923/11/7/300/pdf
    pharmaceutics Review Latest Advances in the Development of Eukaryotic Vaults as Targeted Drug Delivery Systems Amanda Muñoz-Juan 1,y, Aida Carreño 1, Rosa Mendoza 1,2 and José L. Corchero 1,2,3,* 1 Institut de Biotecnologia i de Biomedicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain 2 Networking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 ...Author: Amanda Muñoz-Juan, Aida Carreño, Rosa Mendoza, José L. Corchero

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