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https://clinicalgate.com/rectal-and-vaginal-drug-delivery/
• Rectal and vaginal routes are used for local as well as systemic drug delivery and offer some unique advantages. • Both routes have a use in systemic drug delivery when the oral route is not available. • These routes are relatively less popular because of their anogenital nature and privacy aspects.
http://www.imedpub.com/articles/intra-vaginal-drug-delivery-systeman-overview.pdf
a valuable route for drug delivery through the use of specifically designed carrier systems for both local and systemic applications. Intra-vaginal drug delivery is particularly appropriate for drugs associated with women's health issues but may also have applications in …Author: Chinmaya Keshari Sahoo, Prakash Kumar Nayak, Deepak Kumar Sarangi, Tanmaya Keshari Sahoo
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664883/
Vaginal drug delivery has been used for a number of therapeutic agents such as antibacterial, antifungal, spermicidal, and steroids (56,57). The most common dosage forms utilized in vaginal delivery are also being currently investigated as microbicides (58–62).Author: Lisa Cencia Rohan, Alexandra B. Sassi
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/vaginal-drug-delivery
Vaginal drug delivery of therapeutic moieties is gaining increasing attention because vaginal administration offers several advantages, from avoidance of the first-pass effect when used for systemic therapy to more specific advantages such as relatively easy access, potential for mucoadhesion-prolonged residence time, and potential for self ...
https://www.researchgate.net/publication/221875696_A_review_on_vaginal_drug_delivery_systems
The main objective of the present review is to summarize various vaginal drug delivery systems with an special emphasis an vaginal physiology, factors affecting the vaginal drug absorption ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857731/
Intravaginal delivery of microbicide combinations is a promising approach for the prevention of sexually transmitted infections, but requires a method of providing simultaneous, independent release of multiple agents into the vaginal compartment. A novel ...Author: Marc M. Baum, Irina Butkyavichene, Joshua Gilman, Sean Kennedy, Etana Kopin, Amanda M. Malone, Cali ...
https://stm.sciencemag.org/content/4/138/138ra79.full
Jun 13, 2012 · For vaginal drug delivery to be maximally effective, topically delivered drugs must be distributed uniformly, maintained at sufficiently high concentration, and remained in close proximity to the folded vaginal epithelium (rugae) and cervical mucosa.Author: Laura M. Ensign, Benjamin C. Tang, Benjamin C. Tang, Ying-Ying Wang, Terence A. Tse, Timothy Hoen, R...
http://www.authorstream.com/Presentation/nithin35-2175717-vaginal-drug-delivery/
Jun 08, 2014 · Vaginal rings are circular ring type drug delivery devices designed to release drug in a controlled release fashion after insertion in the vagina. Polymer generally used polydimethyl siloxane ( silicone device) They are 5.5 cm in diameter with a circular cross section diameter of 4-9 mm, where drugs are homogeneously dispersed 1) Vaginal rings 29
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